Summary of project PR002305
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002305. The data can be accessed directly via it's Project DOI: 10.21228/M8PG2P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002305 |
| Project DOI: | doi: 10.21228/M8PG2P |
| Project Title: | ndufs2-/- mitochondrial Leigh syndrome zebrafish model has shortened lifespan, morphologic anomalies, and altered one-carbon metabolism |
| Project Summary: | Targeted metabolomics (LC-MS/MS) on zebrafish larvae samples from a novel human Primary Mitochondrial Disease (PMD) Complex I (CI) deficiency model generated by introducing a deletion to the NDUFS2 gene using CRISPR/Cas9 technology. Healthy zebrafish larvae were to test for differences in metabolite concentrations between healthy and diseased larvae. |
| Institute: | Children's Hospital of Philadelphia |
| Laboratory: | Mitochondrial Medicine Research Group |
| Last Name: | Falk |
| First Name: | Marni |
| Address: | 3615 Civic Center Blvd, Philadephia PA, 19104 |
| Email: | falkm@chop.edu |
| Phone: | 267-426-4961 |
Summary of all studies in project PR002305
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003712 | ndufs2-/- mitochondrial Leigh syndrome zebrafish model has shortened lifespan, morphologic anomalies, and altered one-carbon metabolism | Danio rerio | Children's Hospital of Philadelphia | MS | 2025-08-01 | 1 | 6 | Uploaded data (648.7M)* |
