Summary of project PR002354
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002354. The data can be accessed directly via it's Project DOI: 10.21228/M8BZ5J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002354 |
| Project DOI: | doi: 10.21228/M8BZ5J |
| Project Title: | Chronically ingested nano- and microplastics accumulate in macrophages and perturb their core functions |
| Project Summary: | Plastic pollution has emerged as a global environmental crisis of unprecedented scale. Micro- and nano-plastic (MNPS) pervade ecosystems, resulting in persistent exposure for all living organisms, including humans. MNPs have been detected in human blood, and animal studies indicate their ability to cross biological barriers and accumulate in organs such as the liver, spleen, and brain. However, the effects of plastic accumulation on tissue homeostasis and immune cell function remain poorly understood. This study investigates the consequences of chronic polystyrene particle ingestion using a mouse model. Following oral ingestion, MNPs breach tissue barriers and accumulate in multiple organs. Hepatic and splenic macrophages are pivotal in the uptake and retention of MNPs, leading to their long-term persistence in these tissues. This prolonged presence disrupts metabolic homeostasis in the liver and adipose tissues without inducing systemic inflammation. Moreover, MNPs ingestion exacerbates metabolic dysregulation under additional stress, such as a high-fat diet, worsening glucose intolerance. On a cellular level, MNPs accumulation in Kupffer cells, the liver-resident macrophages, impairs their phagocytic function, reducing their ability to clear circulating bacteria. Additionally, MNP-exposed mice exhibit signs of an autoimmune phenotype. Altogether, our results demonstrate the hazardous nature of MNPs ingestion on tissue homeostasis, metabolism, and macrophage functionality. These findings suggest that chronic exposure to plastic particles could contribute to the rising prevalence of environmentally linked metabolic and autoimmune diseases. |
| Institute: | University of Bonn |
| Department: | Developmental Biology of the Immune System, The Life & Medical Sciences Institute (LIMES) |
| Laboratory: | Mass Lab |
| Last Name: | Makdissi |
| First Name: | Nikola |
| Address: | Carl Troll straße 31, Bonn, nordRhein westfalen, 53115, Germany |
| Email: | nmakdissi@uni-bonn.de |
| Phone: | 02 28 / 73 - 6 2794 |
Summary of all studies in project PR002354
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003776 | Investigation of Hepatic Lipid Alterations Following Micro- and Nanoplastic-Ingestion | Mus musculus | University of Bonn | MS | 2025-03-13 | 1 | 28 | Uploaded data (160.7M)* |
