Summary of project PR002375
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002375. The data can be accessed directly via it's Project DOI: 10.21228/M8N83P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002375 |
| Project DOI: | doi: 10.21228/M8N83P |
| Project Title: | Salivary Metabolome Profiling in Oral Cancer Patients: A Comparative Study. |
| Project Summary: | Objectives: The present study is conducted to investigate the biochemical and pathophysiological changes in saliva of non-smokers controls and oral cancer patients. Materials and methods: Saliva samples collected from a total of 16 oral cancer participants, and 26 non-smoking control individuals were subjected to untargeted metabolomics analysis. Metabolites from the saliva samples of all the participants were analyzed and processed via MetaboScape software version 4 (Bruker, Darmstadt, Germany). Results: We identified 59 differentially abundant salivary metabolites in the comparisons between controls and oral cancer samples. Among the 59 metabolites, 33 were significantly different in oral cancer participants. The top five most abundant metabolites in oral cancer were N-Acetyl-L-alanine, L-Carnitine, Trimethylamine, Acetaminophen, and Oxypurinol.. Conclusions: Salivary metabolomic profiling revealed distinct metabolic alterations in oral cancer patients compared to controls, highlighting potential biomarkers for disease detection and monitoring. Clinical Relevance: Our findings underscore the profound impact of oral cancer on oral biochemistry, potentially predisposing individuals to oncogenic transformations. |
| Institute: | Sharjah Institute for Medical Research |
| Last Name: | Facility |
| First Name: | Core |
| Address: | M32, SIMR, College of Pharmacy, Health Sciences, University of Sharjah, Sharjah, UAE, Sharjah, 000, United Arab Emirates |
| Email: | tims-tof@sharjah.ac.ae |
| Phone: | +971 6 5057656 |
Summary of all studies in project PR002375
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003801 | Salivary Metabolome Profiling in Oral Cancer Patients: A Comparative Study. | Homo sapiens | Sharjah Institute for Medical Research | MS | 2025-09-11 | 1 | 84 | Uploaded data (54.9G)* |
