Summary of project PR002398
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002398. The data can be accessed directly via it's Project DOI: 10.21228/M8P249 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002398 |
| Project DOI: | doi: 10.21228/M8P249 |
| Project Title: | Taurochenodeoxycholic acid levels are associated with scar hypertrophy in the rabbit ear hypertrophic scar model. |
| Project Summary: | The aim of this study was to investigate the relationship between gut microbiota, metabolites and scar hypertrophy using the rabbit ear hypertrophic scar model. On postoperative day 28, the rabbits were divided into scar-susceptible (group H) and scar-insusceptible (group L) groups according to macroscopic scar thickness. Using fecal microbiota transplantation (FMT), we exchanged the gut microbiota of group H and group L. Untargeted metabolomics was performed before and after FMT. We found that in the rabbit ear hypertrophic scar model, scar hypertrophy was more severe in group H and was associated with fecal microbiota and their metabolites. Gut microbiota components and key genera were transferred between group H and group L by FMT, accompanied by altered levels of key metabolites such as TCDCA (bile acid taurochenodeoxycholic acid). FMT relieved scar hypertrophy in group H and vice versa. TCDCA were decreased in group H rabbit and its relative abundance was successfully reversed by heterochronic FMT. |
| Institute: | Shenzhen Center for Chronic Disease Control |
| Department: | Plastic surgery, Shenzhen Institute of Dermatology |
| Last Name: | Liang |
| First Name: | Zhengyun |
| Address: | No. 2021, Buxin Road, Luohu District, Shenzhen, Guangdong, 51802, China |
| Email: | 18819481519@163.com |
| Phone: | 18819481519 |
Summary of all studies in project PR002398
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003839 | Taurochenodeoxycholic acid levels are associated with scar hypertrophy in the rabbit ear hypertrophic scar model. | Oryctolagus cuniculus | Shenzhen Center for Chronic Disease Control | MS* | 2025-05-01 | 1 | 32 | Uploaded data (4.1G)* |
