Summary of project PR002401
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002401. The data can be accessed directly via it's Project DOI: 10.21228/M88V68 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002401 |
| Project DOI: | doi: 10.21228/M88V68 |
| Project Title: | Multiomics Coalescent Analyses Delineates the Complex Anthropogenic Evolution of Silkworm Races in Europe |
| Project Type: | Metabolomics and Lipidomics |
| Project Summary: | Employing phenomics, proteomics, metabolomics and lipidomics, this study identifies the introduction routes and anthropogenic evolution of European silkworm races, a clade of silkworm races with unresolved and obscure ancestry. Prompted by recent findings on the genomic variability that underlies the ancestry and cocoon shell colour of the silkworm, Bombyx mori, we carried out a large-scale analysis of historical and contemporary cocoon shells of this species. By taking our datasets through a series of dimensionality reduction and clustering algorithms, in conjunction with narratives from historical archives that attest to continuous familial interbreeding and constant influx of silkworm races in Europe, we identify three regional hotspots of diversification of these European silkworm races. Furthermore, and in agreement with recent genomic analyses which show an early evolutionary divergence of European silkworm races, we show that these races exhibit human-driven phenotypic innovations, during their domestication in Europe, caused by continuous familial breeding, selection for a limited number of traits and limited regional segregation. Our multiomics datasets provide a valuable foundation for advancing further exploitations of silkworm cocoon shells and show that the European silkworm races are lineages of races that evolved in Central Asia and the Middle East before arriving in Europe and then continuously interbred and improved through introduction of Chinese and Japanese silkworm races. |
| Institute: | National and Kapodistrian University of Athens |
| Department: | Biology |
| Laboratory: | Zoology |
| Last Name: | Dedos |
| First Name: | Skarlatos |
| Address: | Panepistimioupoli Zografou, Athens, Attiki, 15784, Greece |
| Email: | sdedos@biol.uoa.gr |
| Phone: | 0030-2107274705 |
| Funding Source: | This research was founded by the project: Advocating the Role of silk Art and Cultural heritage at National and European scale - Aracne (European Union’s Horizon Europe Research and Innovation Programme: Grant Agreement No 101095188). |
| Project Comments: | This is a study of 80 Bombyx mori cocoon shell samples analysed for their metabolites and lipids content |
| Publications: | Pending |
| Contributors: | Panagiota Fragkoua, Ioannis Martakosb, Georgia Rounic, Demetrios Vasilakosa, Evangelos Koutsoukosa, Alesssio Savianed, Silvia Cappellozzad, Marios G. Kostakisb, Martina Samiotakic, Sotiris Kotsiantise, Mariana Barcenasf**, Skarlatos G. Dedosa* |
Summary of all studies in project PR002401
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003842 | Lipidomics Analysis of the Silkworm Cocoon Shell | Bombyx mori | National and Kapodistrian University of Athens | MS | 2025-07-15 | 1 | 100 | Uploaded data (40.3G)* |
| ST003843 | Metabolomics Analysis of the Silkworm Cocoon Shell | Bombyx mori | National and Kapodistrian University of Athens | MS | 2025-07-15 | 1 | 100 | Uploaded data (21.8G)* |
