Summary of project PR002430
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002430. The data can be accessed directly via it's Project DOI: 10.21228/M8J53Q This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002430 |
| Project DOI: | doi: 10.21228/M8J53Q |
| Project Title: | Alkyglycerol monooxygenase represses prostanoid biosynthesis in a sex-dependent manner |
| Project Summary: | Ether lipids are major constituents of biomembranes and often contain polyunsaturated fatty acids at the sn-2 position, implicating them in cellular signaling and inflammatory processes. Alkylglycerol monooxygenase is the only enzyme capable of cleaving alkylglycerols, an ether lipid subclass, but its exact role and that of its substrates remain unclear. Here, we demonstrate a sex- and cell type-dependent role of alkylglycerol monooxygenase in limiting prostanoid formation without affecting polyunsaturated fatty acid release, as revealed by metabololipidomics profiling. This female-specific effect is driven by the suppression of prostaglandin G/H synthase 2 transcription, as deficiency in alkylglycerol monooxygenase significantly elevated prostaglandin G/H synthase 2 expression in female bone marrow-derived macrophages of the M1 phenotype. Furthermore, this regulatory role of alkylglycerol monooxygenase extends to visceral white adipose tissue, where elevated prostaglandin G/H synthase 2 expression and enhanced prostaglandin production were observed in female samples following alkylglycerol monooxygenase knockout. Collectively, our results expand the immunomodulatory functions of ether lipid metabolism and highlight the role of alkylglycerol monooxygenase in controlling lipid mediator production and maintaining tissue homeostasis. |
| Institute: | University of Innsbruck |
| Department: | Michael Popp Institute |
| Last Name: | Rao |
| First Name: | Zhigang |
| Address: | Mitetrweg 24, Innsbruck, Tyrol, 6020, Austria |
| Email: | rzgwuda@gmail.com |
| Phone: | +43 662 8044 5581 |
| Publications: | in revision |
| Contributors: | Zhigang Rao, Andreas Koeberle |
Summary of all studies in project PR002430
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003876 | Exploration of AGMO-dependent changes in the lipid mediator profile of polarized BMDM cells (M0, M1 and M2 phenoptypes) | Mus musculus | University of Innsbruck | MS | 2025-04-28 | 1 | 153 | Uploaded data (48.9M)* |
