Summary of project PR002434
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002434. The data can be accessed directly via it's Project DOI: 10.21228/M81532 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002434 |
| Project DOI: | doi: 10.21228/M81532 |
| Project Title: | Untargeted metabolome analysis of intervertebral disc tissue |
| Project Type: | UHPLC-MS/MS untargeted Metabolomics |
| Project Summary: | Intervertebral disc degeneration (IVDD) is a multifactorial disease which causes structural and biochemical changes that leads to disability. Identifying the molecular signatures in the intervertebral disc (IVD) during degeneration is crucial to understand the disease pathogenesis. The study aims to identify the metabolic alterations during IVD degeneration. Control and disease IVD tissues were collected and the metabolites were extracted from nucleus pulposus tissue (NP) using triple solvent mixture (Methanol: Acetonitrile: Methanol with 2:2:1 ratio) and profiled using UHPLC-ESI-MS/MS. Untargeted metabolomics identified 832 metabolites from control and disease samples. Differential analysis revealed alterations in amino acids and lipids predominantly. |
| Institute: | Ganga Orthopaedic Research and Education Foundation |
| Department: | Proteomics |
| Laboratory: | Proteomics |
| Last Name: | Tangavel |
| First Name: | Dr. Chitraa |
| Address: | Ganga Research Centre, 442, Vattamalaipalayam, NGGO Colony, Coimbatore-641022, Coimbatore, Tamil Nadu, 641022, India |
| Email: | cthangavel@gmail.com |
| Phone: | +91 8870009209 |
| Funding Source: | AO-Spine Start-Up research Grant 2023-2024 and Ganga Orthopaedic Research and Education Foundation (GOREF) Funding |
| Publications: | In Progress |
| Contributors: | Divya Arunachalam, Sharon Miracle Nayagam, Murugesh Easwaran, Sunmathi Rajendran, Karthik Ramachandran, Sri Vijay Anand, Chitra Tangavel, Rajasekaran Shanumganathan |
Summary of all studies in project PR002434
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003880 | Untargeted metabolome analysis of control and disease intervertebral disc tissue | Homo sapiens | Ganga Orthopaedic Research and Education Foundation | MS | 2025-05-21 | 1 | 61 | Uploaded data (42G)* |
