Summary of project PR002435
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002435. The data can be accessed directly via it's Project DOI: 10.21228/M8WG2J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002435 |
| Project DOI: | doi: 10.21228/M8WG2J |
| Project Title: | Lipidomic alterations after a single session with ayahuasca in health and depression: a randomized placebo-controlled trial |
| Project Type: | MS untargeted analysis |
| Project Summary: | Major depressive disorder (MDD) affects 3.8 % of the world population and there is an estimative that at least 30 % of patients have partial or no response to treatments, which is a relevant healthcare concern. Ayahuasca is an indigenous psychedelic beverage, usually prepared from Banisteriopsis caapi and Psychotria viridis, which has been described in the scientific literature as presenting antidepressant effects. In order to investigate the mechanisms behind MDD and ayahuasca treatment at a molecular level, untargeted lipidomic analyses were carried out on blood serum samples from patients diagnosed with treatment-resistant depression (TRD) and control subjects given ayahuasca or placebo in a double-blind design. Results indicated the participation mainly of the immune system in TRD pathophysiology and in the antidepressant effects of ayahuasca, as well as the involvement of hypothalamic-pituitary-adrenal (HPA) axis and microbiota. |
| Institute: | University of Campinas |
| Department: | Chemistry's Institute |
| Laboratory: | Laboratory of Bioanalytics and Integrated Omics |
| Last Name: | Matos |
| First Name: | Taynara |
| Address: | Rua Josué de Castro, s/n – Cidade Universitária, 13083-970, Campinas – SP, Brazil |
| Email: | t262827@dac.unicamp.br |
| Phone: | (85)996154192 |
Summary of all studies in project PR002435
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003882 | Lipidomic alterations after a single session with ayahuasca in health and depression: a randomized placebo-controlled trial | Homo sapiens | University of Campinas | MS* | 2025-05-16 | 1 | 102 | Uploaded data (1.1G)* |
