Summary of project PR002440
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002440. The data can be accessed directly via it's Project DOI: 10.21228/M87N91 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002440 |
| Project DOI: | doi: 10.21228/M87N91 |
| Project Title: | Loss of tty alters lipid profile in Drosophila brains |
| Project Summary: | Tweety homolog 1 (TTYH1) is an understudied protein designated by the Illuminating the Druggable Genome Program of the NIH. While previous studies implicated its functions in neural stem cell signaling and glioma invasion, little is known about the molecular function of TTYH1. Recent cryo-electron microscopy examination of TTYH1 revealed its potential role in transporting membrane lipids, leading to our hypothesis that TTYH1 regulates intracellular lipid homeostasis. Orthologs of TTYH1 have been identified across animal species including worm and fruit fly. Similar to human TTYH1, fly TTYH1 ortholog, named tweety (tty), is also predominantly expressed in the brain. To examine whether TTYH1 exerts its cellular functions via regulating lipid homeostasis, we profiled the lipidome in fruit fly (Drosophila melanogaster) head tissues isolated from wild-type (w-1118 strain) and tty mutant (tty-MI12269 strain) flies. |
| Institute: | Rutgers University Newark |
| Laboratory: | Ching-On Wong |
| Last Name: | Wong |
| First Name: | Ching-On |
| Address: | 195 University Avenue, Boyden Hall Room 206, Newark, NJ 07102 |
| Email: | chingon.wong@rutgers.edu |
| Phone: | 9733530832 |
| Contributors: | Ho Hang Leung, Ching-On Wong, Yujue Wang, Xiaoyang Su |
Summary of all studies in project PR002440
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003899 | Lipidome profiling of fly head tissues from wild-type and tty mutant flies (cohort 1) | Drosophila melanogaster | Rutgers University | MS | 2025-05-28 | 1 | 8 | Uploaded data (213.4M)* |
| ST003900 | Lipidome profiling of fly head tissues from wild-type and tty mutant flies (cohort 2) | Drosophila melanogaster | Rutgers University | MS | 2025-05-28 | 1 | 6 | Uploaded data (164.6M)* |
