Summary of project PR002450
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002450. The data can be accessed directly via it's Project DOI: 10.21228/M8Z84V This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002450 |
| Project DOI: | doi: 10.21228/M8Z84V |
| Project Title: | Gut Microbial Bile and Amino Acid Metabolism Associate with Peanut Oral Immunotherapy Failure |
| Project Summary: | Peanut Oral Immunotherapy (POIT) holds promise for remission of peanut allergy, though treatment is protracted and successful in only a subset of patients. Because the gut microbiome has been linked to food allergy, we sought to identify fecal predictors of POIT efficacy and mechanistic insights into treatment response. Longitudinal analysis of fecal microbiomes of children (n=90) in a double-blind, placebo-controlled POIT trial (NCT01867671) revealed a relationship between gut microbiome metabolic capacity and treatment outcomes. Five fecal bile acids (BAs) present prior to treatment initiation predicted POIT efficacy (AUC 0.71). Treatment failure was associated with a specific BA profile, enhanced amino acid utilization, and higher copy number of the ptpA gene encoding a bacterial hydrolase that cleaves tripeptides containing proline residues – a feature of immunogenic peanut Ara h 2 proteins. In vitro, peanut-supplemented fecal cultures of children for whom POIT failed to induce remission evidenced reduced Ara h 2 concentrations. Thus, distal gut microbiome metabolism appears to contribute to POIT failure. |
| Institute: | University of California, San Francisco |
| Last Name: | Ozcam |
| First Name: | Mustafa |
| Address: | 513 Parnassus S363 |
| Email: | m.ozcam19@gmail.com |
| Phone: | 3023575858 |
| Funding Source: | NIAID, NIH |
| Publications: | https://www.medrxiv.org/content/10.1101/2024.07.15.24309840v1 |
Summary of all studies in project PR002450
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003917 | Gut Microbial Bile and Amino Acid Metabolism Associate with Peanut Oral Immunotherapy Failure | Homo sapiens | University of California, San Francisco | MS | 2025-06-02 | 1 | 177 | Not available |
