Summary of project PR002457
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002457. The data can be accessed directly via it's Project DOI: 10.21228/M81Z64 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002457 |
| Project DOI: | doi: 10.21228/M81Z64 |
| Project Title: | Urinary metabolomic profiling in pediatric primary mitochondrial disease (PMD) and chronic kidney disease (CKD) |
| Project Type: | Prospective |
| Project Summary: | Untargeted ¹H-NMR metabolomics analysis of urine samples from pediatric patients with primary mitochondrial disease (PMD), secondary mitochondrial dysfunction (SMD), chronic kidney disease (CKD), patients with PMD and CKD, and healthy controls. Spectra were normalized to total spectral area and 60 samples were included after quality control. |
| Institute: | University of Aveiro |
| Department: | Reference Center for Inherited Metabolic Disorders, Centro Hospitalar Universitario de Santo António, Unidade Local de Saúde de Santo António |
| Laboratory: | Chemistry Department - Universidade de Aveiro |
| Last Name: | Paiva Coelho |
| First Name: | Margarida |
| Address: | Largo da Maternidade S/N, 4050 Porto |
| Email: | mmargaridacoelho.dca@chporto.min-saudept |
| Phone: | +351913448849 |
| Funding Source: | This study was funded by a grant from Pfizer Vaccines / SPP 2019. This work was developed within the scope of the CICECO-Aveiro Institute of Materials, UIDB/50011/2020 project (doi: 10.54499/UIDB/50011/2020), UIDP/50011/2020 (doi: 10.54499/UIDP/50011/2020) and LA/P/0006/2020 (doi:10.54499/LA/P/0006/2020), financed by national funds through the FCT/MCTES (PIDDAC). We also acknowledge funds from the Foundation for Science and Technology through the BetterBone project (2022.04286.PTDC, doi: 10.54499/2022.04286.PTDC), the Portuguese National NMR Network (RNRMN), supported by Infrastructure Project Nº 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). |
| Project Comments: | This project includes ¹H-NMR-based untargeted metabolomic profiling of urine in mitochondrial disorders. Data includes raw Bruker spectra and processed bin-integrated matrices. |
| Publications: | to be submitted |
| Contributors: | Margarida Paiva Coelho, Teresa Costa, Aureliano Dias, Inês C.R. Graça, Hugo Rocha, Laura Vilarinho, Esmeralda Martins, João E. Rodrigues, Ana M. Gil |
Summary of all studies in project PR002457
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003924 | NMR-based Urinary Biomarkers in Pediatric Primary Mitochondrial Disorders and Chronic Kidney Disease: Shared Mitochondrial Dysfunction, Diverging Biosignatures | Homo sapiens | University of Aveiro | NMR* | 2025-11-19 | 1 | 65 | Uploaded data (59.2M)* |
