Summary of project PR002504
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002504. The data can be accessed directly via it's Project DOI: 10.21228/M8ZV87 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002504 |
| Project DOI: | doi: 10.21228/M8ZV87 |
| Project Title: | Measuring PEMT activity in HCMV infected fibroblasts using 13C-methionine. |
| Project Summary: | Human cytomegalovirus (HCMV) is a common herpesvirus that establishes a lifelong and persistent infection in its human host. HCMV infection in most people does not cause overt disease. However, in immunocompromised individuals, severe CMV-associated disease can lead to permanent disabilities and even death. Additionally, congenital CMV is the leading infectious cause of birth defects. Viruses have evolved to hijack host metabolic pathways to facilitate their replication cycle. We previously reported HCMV infection increases phosphatidylcholine (PC) lipid levels, including PCs with VLCFAs. To expand upon the previously reported PC phenotype in HCMV infection, we determined the PC lipidome of several infected cell types grown under various growth conditions. Additionally, we determined which host pathways HCMV reprograms to induce PC lipid synthesis and describe when during infection PC lipids changes occur. |
| Institute: | University of Arizona |
| Department: | Immunobiology |
| Laboratory: | John G. Purdy, PhD |
| Last Name: | Kline |
| First Name: | Ian |
| Address: | 1657 E Helen St, Tucson, AZ 85721 |
| Email: | ikline@arizona.edu |
| Phone: | 5209092596 |
| Funding Source: | National Institute of Health (NIH) National Institute of Allergy and Infectious Disease (NIAID) R01AI162671, R01AI155539, F32AI178919, and National Institute of Aging (NIA) T32AG058503 award. |
Summary of all studies in project PR002504
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST003999 | Measuring PEMT activity in HCMV infected fibroblasts using 13C-methionine. | Homo sapiens | University of Arizona | MS | 2025-06-25 | 1 | 88 | Uploaded data (1.2G)* |
