Summary of project PR002522
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002522. The data can be accessed directly via it's Project DOI: 10.21228/M8NG10 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002522 |
| Project DOI: | doi: 10.21228/M8NG10 |
| Project Title: | StAR-MS for indole derivative discovery in mice feces |
| Project Summary: | Human intestinal microbiota exert significant influences on host physiology through bioactive molecules. Indole derivatives, a diverse class of organic compounds arising from microbial-mediated tryptophan metabolism, play pivotal roles in maintaining metabolic homeostasis and disease progression. The characteristic aromatic heterocycle substructure shared in various indole derivatives is intrinsically associated with the activation of aryl hydrocarbon receptor (AhR), suggesting a potential structure-activity relationship (SAR) which remains underexplored. In the present study, we developed a structure-to-activity relationship metabolomics (StAR-MS) pipeline that aims at elucidating the SAR information embedded within metabolomics data, further applied it to identify novel gut microbiome-derived, indole-like derivatives with potential AhR agonistic activity. A total of 22 metabolites exhibiting activity-related substructures were identified, four of which were characterized for the first time. |
| Institute: | University of North Carolina at Chapel Hill |
| Department: | ESE |
| Laboratory: | Lu lab |
| Last Name: | Zhao |
| First Name: | Haoduo |
| Address: | 135 Dauer Drive Chapel Hill, NC 27599-7400 |
| Email: | raven456@unc.edu |
| Phone: | 9845281428 |
Summary of all studies in project PR002522
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004030 | StAR-MS for indole derivative discovery in mice feces | Mus musculus | University of North Carolina at Chapel Hill | MS | 2025-07-30 | 1 | 27 | Uploaded data (5.1G)* |
