Summary of project PR002524
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002524. The data can be accessed directly via it's Project DOI: 10.21228/M8CZ4G This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002524 |
| Project DOI: | doi: 10.21228/M8CZ4G |
| Project Title: | SIRT3 induces cell senescence via regulating deacetylation of SLC25A13 in colorectal cancer |
| Project Type: | research |
| Project Summary: | We demonstrate that SIRT3 knockdown induces mitochondrial dysfunction-associated senescence (MiDAS) in colorectal cancer (CRC) cells. Mechanistically, hyperacetylation of SLC25A13—a SIRT3 substrate—compromises its function, leading to a reduced cytosolic NAD+/NADH ratio and subsequent senescence. Furthermore, employing a 'hit-and-run' screening strategy, we identified senolytic agents capable of selectively eliminating senescent tumor cells, providing potential therapeutic avenues for CRC treatment |
| Institute: | Sichuan University |
| Department: | Cancer Center and State Key Laboratory of Biotherapy |
| Laboratory: | Cancer Center and State Key Laboratory of Biotherapy |
| Last Name: | WEI |
| First Name: | LIU |
| Address: | Linyin street, Chengdu, sichuan province, 610041, China |
| Email: | lwwl1995@163.com |
| Phone: | 18030469801 |
Summary of all studies in project PR002524
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004032 | SIRT3 induces cell senescence via regulating deacetylation of SLC25A13 in colorectal cancer | Homo sapiens | Sichuan University | MS | 2025-07-31 | 1 | 24 | Uploaded data (1.7G)* |
