Summary of project PR002526
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002526. The data can be accessed directly via it's Project DOI: 10.21228/M84G0Z This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002526 |
| Project DOI: | doi: 10.21228/M84G0Z |
| Project Title: | A Multi-Tissue Lipidome and Adipose Proteome Atlas Reveals Perinatal Bisphenol S Exposure Primes Offspring for High-Fat Diet-Induced Obesity and Insulin Resistance |
| Project Summary: | Due to increasingly strict regulations on the use of bisphenol A (BPA), its structurally similar alternative, bisphenol S (BPS), has been widely used as a major substitute in many industries, including food packaging. However, recent studies have revealed that BPS may promote obesity and lead to insulin resistance, especially in the early stages of life, although its exact impact is not yet fully understood. To address these concerns, this study established a mouse model to explore the exposure of female mice to BPS during pregnancy and lactation, as well as the consumption of high-fat diets by their offspring. By evaluating the biological phenotypes related to obesity and insulin resistance in the offspring mice, multi-tissue lipidomics analysis and adipose tissue proteomics analysis were carried out. Ultimately, a correlation study was conducted by combining phenotypes, lipidomics, and proteomics to explore the risks and potential mechanisms of BPS exposure to obesity and insulin resistance. |
| Institute: | Jimei University |
| Last Name: | Li |
| First Name: | Shuyin |
| Address: | No. 185 Yinjiang Road, Jimei District, Xiamen City, Fujian Province, China |
| Email: | 164000107@qq.com |
| Phone: | 18750682266 |
Summary of all studies in project PR002526
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004034 | A Multi-Tissue Lipidome and Adipose Proteome Atlas Reveals Perinatal Bisphenol S Exposure Primes Offspring for High-Fat Diet-Induced Obesity and Insulin Resistance | Mus musculus | Jimei University | MS* | 2025-07-31 | 1 | 275 | Uploaded data (45.1G)* |
