Summary of project PR002529
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002529. The data can be accessed directly via it's Project DOI: 10.21228/M8R840 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002529 |
| Project DOI: | doi: 10.21228/M8R840 |
| Project Title: | Untargeted Metabolomics Reveal Long-Term Metabolic Changes in the Oral Cavity Following Disease Stress and Recovery (University of Michigan) |
| Project Type: | Human longitudinal study |
| Project Summary: | This study investigates the temporal metabolomic dynamics of saliva during experimentally induced gingivitis in healthy individuals. Using a no-brushing model over 21 days followed by recovery, we collected saliva from 20 subjects across seven time points and analyzed extracted metabolites with n=14 via LC-MS/MS. The study highlights persistent metabolic signatures even after clinical recovery, suggesting a metabolic lag behind microbial resolution. |
| Institute: | University of Michigan |
| Department: | Life Science Institute |
| Laboratory: | Sherman Laboratory |
| Last Name: | Okiye |
| First Name: | Maribel |
| Address: | 201 Washtenaw Ave |
| Email: | maribelo@umich.edu |
| Phone: | maribelo@umich.edu |
| Project Comments: | Metabolomics study includes two extraction protocols, multiple time points, and matched microbial data. |
| Publications: | doi: https://doi.org/10.1101/2023.06.26.546600 |
| Contributors: | Maribel E. Okiye, Michelle A. Velez, Victoria Voung, Janet Kinney, James Sugai, William V. Giannobile, Ashootosh Tripathi, and David H Sherman |
Summary of all studies in project PR002529
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004037 | Untargeted Metabolomics Reveal Long-Term Metabolic Changes in the Oral Cavity Following Disease Stress and Recovery | Homo sapiens | University of Michigan | MS* | 2025-07-17 | 1 | 777 | Uploaded data (5.7G)* |
