Summary of project PR002547
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002547. The data can be accessed directly via it's Project DOI: 10.21228/M8DR87 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002547 |
| Project DOI: | doi: 10.21228/M8DR87 |
| Project Title: | Microglial and Non-Microglial Regulation of Lipid Metabolism in Alzheimer's Revealed by Genetic and Pharmacological Depletion |
| Project Summary: | Abnormal lipid metabolism is observed in Alzheimer’s disease (AD), but its contribution to disease progression remains unclear. Genetic studies indicate that microglia, the brain’s resident immune cells, influence lipid processing during AD. Here we show that, in both mouse models of AD and human postmortem brain tissue, microglia regulate the accumulation of specific lipids associated with disease pathology. Using multidimensional mass spectrometry-based shotgun lipidomics and histological analysis, we find that arachidonic acid-containing bis(monoacylglycero)phosphate (BMP) accumulates in response to amyloid plaques, and this buildup depends on microglial function and the AD risk gene progranulin (GRN). In contrast, lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE) accumulate independently of microglia, instead associating with astrocyte activation and oxidative stress. These findings connect dysregulated lipid metabolism in AD to distinct brain cell types and molecular pathways. The results suggest that microglial regulation of lipid homeostasis is a potential therapeutic target for AD. |
| Institute: | UT Health San Antonio |
| Department: | Department of Medicine |
| Laboratory: | Xianlin Han Lab |
| Last Name: | Han |
| First Name: | Xianlin |
| Address: | 7703 Floyd Curl Drive |
| Email: | hanx@uthscsa.edu |
| Phone: | 2105624104 |
Summary of all studies in project PR002547
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004057 | Microglial and Non-Microglial Regulation of Lipid Metabolism in Alzheimer's Revealed by Genetic and Pharmacological Depletion | Homo sapiens; Mus musculus | UT Health San Antonio | MS | 2025-08-14 | 1 | 108 | Uploaded data (7.5G)* |
