Summary of project PR002561
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002561. The data can be accessed directly via it's Project DOI: 10.21228/M8MC3D This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002561 |
| Project DOI: | doi: 10.21228/M8MC3D |
| Project Title: | Revealing metabotypes of IgE-, COX-1 inhibitors- and MRGPRX2 receptor-mediated drug hypersensitivities |
| Project Type: | Lipidomics untargeted MS |
| Project Summary: | Despite their clinical relevance, the immunological mechanisms underlying immediate drug hypersensitivity reactions (iDHR) are unclear. This study therefore explores the metabolic endotypes (metabotypes) of IgE-, cyclooxygenase (COX)-1 inhibitor-, and Mas-related G-protein coupled receptor X2 (MRGPRX2)-mediated iDHR. Serum samples obtained from 19 patients during the acute and baseline stages of iDHR were analyzed using liquid chromatography coupled to mass spectrometry (LC-MS)-based untargeted metabolomics. Different immunological mechanisms were found to induce distinct metabotypes. The main metabolic classes implicated were amino acids, acyl carnitines, fatty acids, and lysophospholipids, such as lysophosphatidylcholines (LPC) and lysophosphatidylethanolamines (LPE). Most of these compounds decreased during the acute phase of iDHR and exhibited varying trends among the three types of iDHR. |
| Institute: | Universidad CEU San Pablo |
| Department: | Chemistry and Biochemistry |
| Laboratory: | CEMBIO |
| Last Name: | Neuhaus |
| First Name: | René |
| Address: | Urb. Montepríncipe, Alcorcón, Madrid, 28925, Spain |
| Email: | rene.neuhaus@ceu.es |
| Phone: | +34611042778 |
Summary of all studies in project PR002561
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004080 | Revealing metabotypes of IgE-, COX-1 inhibitors- and MRGPRX2 receptor-mediated drug hypersensitivities | Homo sapiens | Universidad CEU San Pablo | MS* | 2025-08-19 | 1 | 47 | Uploaded data (1.5G)* |
