Summary of project PR002609
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002609. The data can be accessed directly via it's Project DOI: 10.21228/M8DG1T This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002609 |
| Project DOI: | doi: 10.21228/M8DG1T |
| Project Title: | Urinary Multi-Omics Signatures of Preterm Premature Rupture of Membranes: Insights into Microbial and Metabolic Biomarkers |
| Project Summary: | Preterm premature rupture of membranes (PPROM) is a significant obstetric complication, often associated with infection-related processes. However, the underlying mechanisms remain poorly understood, particularly regarding the interplay between microbial dysbiosis and host metabolism. To address this, urine samples from women with PPROM and healthy controls were analyzed using 16S rRNA gene sequencing and ¹H NMR-based metabolomics. Microbiota analysis revealed increased abundance of Hoylesella, Escherichia, Pseudomonas, and Enterococcus in the PPROM group, whereas Lactobacillus and Limosilactobacillus dominated in controls. Metabolomics identified key metabolites with diagnostic potential. Receiver operating characteristic (ROC) analysis showed that hippurate, formate, citrate, glycolate, serine, valine, and isoleucine had high discriminatory accuracy (AUC > 0.7), while β-glucose, asparagine, pyroglutarate, 2-hydroxyglutarate, tyrosine, creatinine, and imidazole had moderate predictive power. The PPROM group exhibited increased valine, isoleucine, asparagine, and β-glucose, while others decreased compared to controls. Multi-omics integration revealed robust correlations between specific bacterial species and urinary metabolites, suggesting interactions between microbial dysbiosis and host metabolic pathways. These findings demonstrate distinct microbial and metabolic signatures in the urine of women with PPROM and support the utility of urinary multi-omics analysis in advancing understanding of PPROM pathophysiology. |
| Institute: | Inonu University Department of Biomedical Eng. |
| Last Name: | Dogan |
| First Name: | Berat |
| Address: | Universite Mah. Muhendislik Fakultesi F-Blok No:1-1, Battalgazi, Malatya, 44280, Turkey |
| Email: | berat.dogan@inonu.edu.tr |
| Phone: | +90 422 3774908 |
Summary of all studies in project PR002609
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004147 | Urinary Multi-Omics Signatures of Preterm Premature Rupture of Membranes: Insights into Microbial and Metabolic Biomarkers | Homo sapiens | Inonu University Department of Biomedical Eng. | NMR | 2025-10-08 | 1 | 78 | Uploaded data (39.7M)* |
