Summary of project PR002635
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002635. The data can be accessed directly via it's Project DOI: 10.21228/M82253 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002635 |
| Project DOI: | doi: 10.21228/M82253 |
| Project Title: | Tomato-Soy Juice Reduces Inflammation and Modulates Urinary Metabolome in Adults with Obesity |
| Project Summary: | Scope: Chronic, low-grade inflammation is a hallmark of many noncommunicable diseases, including obesity. Diets enriched with tomatoes and soy have been associated with better health outcomes in inflammation-related illnesses, with lycopene and isoflavones considered key bioactive components, respectively. On the basis that whole food combinations may exert greater effects than isolated phytochemicals, we examine the anti-inflammatory and metabolic effects of tomato-soy juice compared to a low carotenoid tomato juice control in obesity. Methods and results: In a randomized, crossover trial, 12 healthy adults with obesity were provided either tomato-soy juice (54 mg lycopene/d, 189.9 mg isoflavones/d) or a low carotenoid tomato juice (no isoflavones) daily for 4 weeks, then crossed over to the other treatment following a washout period. Plasma carotenoids, cytokines, and the urine metabolome were measured pre- and post-interventions. Plasma lycopene significantly increased by 2.48-fold after tomato-soy intake. IL-5, IL-12p70, and GM-CSF significantly decreased (P < 0.05), and TNF-alpha trended downward (P = 0.052) following tomato-soy. Soy isoflavones and their metabolites primarily distinguished post-tomato-soy urine profiles. Both interventions induced some shared metabolomic changes in the urine, indicating tomato-driven effects independent of lycopene. Conclusion: Tomato-soy intake reduced some pro-inflammatory cytokines and altered the urine metabolomic profile in adults with obesity, supporting future studies using this functional food product for other inflammation-related conditions. |
| Institute: | Ohio State University |
| Last Name: | Cooperstone |
| First Name: | Jessica |
| Address: | 2255 Kenny Rd |
| Email: | cooperstone.1@osu.edu |
| Phone: | 614-292-2843 |
Summary of all studies in project PR002635
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004178 | Tomato-Soy Juice Reduces Inflammation and Modulates Urinary Metabolome in Adults with Obesity | Homo sapiens | Ohio State University | MS* | 2025-09-30 | 1 | 192 | Uploaded data (17.7G)* |
