Summary of project PR002637
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002637. The data can be accessed directly via it's Project DOI: 10.21228/M8SK0W This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002637 |
| Project DOI: | doi: 10.21228/M8SK0W |
| Project Title: | The Ability of Dietary Polyunsaturated Fatty Acids to Protect Against Liver Inflammation and Non-Alcoholic Steatohepatitis (NASH) is Dependent on Gut Microbes |
| Project Summary: | Non-alcoholic steatohepatitis (NASH) is a rapidly expanding form of liver disease associated with increased risk of cardiometabolic pathologies. Several clinical trials have shown that dietary ω3 polyunsaturated fatty acid (PUFA) supplementation, in particular eicosapentaenoic acid (EPA, 20:5,ω3) and docosahexaenoic acid (DHA, 22:6,ω3), improves health outcomes in NASH patients and lowers cardiovascular diseases. It is shown that ω3 PUFAs can suppress hepatic lipogenesis, resolve hepatic inflammation, and lower plasma triglycerides by reducing the production of hepatic very low-density lipoprotein. In parallel, there is emerging evidence that the gut microbiome can powerfully impact NASH via similar mechanisms. Although dietary PUFA supplementation can strongly impact host lipid metabolic pathways in the liver, it is often overlooked that gut microbiota can also synthesize and degrade diverse lipids. Here, we hypothesized that the ability of dietary PUFAs to suppress NASH and cardiometabolic diseases is dependent on microbe-host co-metabolism of lipids. This study provides a comprehensive lipidomic analysis defining unique dietary fatty acid-microbe-host interactions and have uncovered new insights into how meta-organismal metabolism impacts liver diseases and metabolic disorders. |
| Institute: | Cleveland Clinic |
| Department: | Cardiovascular and Metabolic Sciences |
| Laboratory: | Brown Lab |
| Last Name: | Brown |
| First Name: | J. Mark |
| Address: | 9500 Euclid Avenue, Cleveland, Ohio, 44196, USA |
| Email: | brownm5@ccf.org |
| Phone: | 216 444 8340 |
Summary of all studies in project PR002637
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004181 | The Ability of Dietary Polyunsaturated Fatty Acids to Protect Against Liver Inflammation and Non-Alcoholic Steatohepatitis (NASH) is Dependent on Gut Microbes | Mus musculus | Cleveland Clinic | MS* | 2025-09-28 | 1 | 122 | Uploaded data (25G)* |
