Summary of project PR002640
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002640. The data can be accessed directly via it's Project DOI: 10.21228/M8DC3J This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002640 |
| Project DOI: | doi: 10.21228/M8DC3J |
| Project Title: | Maternal and fetal Tryptophan-Kynurenine metabolite changes in Preeclampsia and Gestational Diabetes |
| Project Type: | Metabolomics |
| Project Summary: | Preeclampsia (PE) and gestational diabetes mellitus (GDM) are major pregnancy complications associated with maternal and neonatal morbidity, including fetal growth restriction and preterm birth. Both disorders involve systemic metabolic dysregulation; however, their effects on maternal and neonatal metabolomic profiles, especially in the Indian population, remain underexplored. In this prospective cohort study, maternal serum and neonatal cord blood were analyzed using ultra-high performance liquid chromatography coupled with Orbitrap mass spectrometry. Differential metabolites were identified and subjected to pathway enrichment and correlation analysis with clinical traits. Distinct metabolomic alterations were observed in maternal and neonatal samples from PE and GDM groups, with notable overlap in neonatal profiles despite differing maternal conditions. Dysregulation of tryptophan–kynurenine (TRP–KYN) pathway metabolites, including kynurenine, quinolinic acid, and serotonin, emerged in both groups and correlated with gestational age, placental weight, vitamin D status, and neonatal bone mineral density. Pathway analysis further highlighted disruptions across multiple metabolic pathways. These findings demonstrate metabolic perturbations in PE and GDM, underscoring the TRP–KYN pathway as a shared feature influencing fetal development. This pathway may serve as a biomarker and therapeutic target, warranting validation in larger cohorts and deeper molecular investigation. |
| Institute: | Translational Health Science And Technology Institute (THSTI) |
| Department: | NCD |
| Laboratory: | Biomarker lab |
| Last Name: | Kumar |
| First Name: | Yashwant |
| Address: | NCR Biotech Science Cluster,, Faridabad, Haryana, 121001, India |
| Email: | y.kumar@thsti.res.in |
| Phone: | 01292876496 |
| Funding Source: | THSTI |
Summary of all studies in project PR002640
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004185 | Maternal and fetal Tryptophan-Kynurenine metabolite changes in Preeclampsia and Gestational Diabetes | Homo sapiens | Translational Health Science And Technology Institute (THSTI) | MS* | 2025-10-06 | 1 | 60 | Uploaded data (6.6G)* |
