Summary of project PR002653
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002653. The data can be accessed directly via it's Project DOI: 10.21228/M8QN9C This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002653 |
| Project DOI: | doi: 10.21228/M8QN9C |
| Project Title: | A taxon-specific measurement of disruption in a multi-modal study of microbiomes and metabolomes reveals system-wide dysbiosis preceding HIV-1 infection |
| Project Summary: | The microbiome is important in immune responses and inflammation in HIV-1 infection. Hence, a deeper understanding of the microbiome prior to HIV-1 infection is potentially important for HIV-1 prevention strategies. Using stool, oral washes, and plasma biospecimens obtained from HIV-1 negative men who have sex with men (MSM), we found several differences in microbial ecologies, gene functions, and metabolites between MSM who became HIV-1 infected approximately 6 months later and those who remained HIV-1 uninfected. The HIV-1 infected MSM had an enrichment of enzymes involved in purine metabolism, lower amino acid metabolism, and higher oxidative stress before the infection. Using a novel taxon-specific measure of DISruption in COrrelations (DISCO) with various data modalities, we identified several gut and oral species with disrupted correlations prior to HIV-1 infection. Application of DISCO to external datasets revealed that Prevotella spp. are consistently disrupted in their correlations across multiple cohorts prior to or following HIV-1 infection. |
| Institute: | National Institute of Environmental Health Sciences |
| Last Name: | Fouladi |
| First Name: | Farnaz |
| Address: | 111 T.W. Alexander Drive, Durham, NC 27709 |
| Email: | farnaz.fouladi@nih.gov |
| Phone: | 984-287-4663 |
Summary of all studies in project PR002653
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004208 | Plasma Metabolomics Profiling in Men Who Have Sex with Men Before HIV-1 Infection | Homo sapiens | National Institute of Environmental Health Sciences | MS* | 2025-10-12 | 1 | 235 | Uploaded data (47.9G)* |
| ST004209 | Oral Metabolomics Profiling in Men Who Have Sex with Men Before HIV-1 Infection | Homo sapiens | National Institute of Environmental Health Sciences | MS* | 2025-10-12 | 1 | 237 | Uploaded data (55.6G)* |
| ST004210 | Stool Metabolomics Profiling in Men Who Have Sex with Men Before HIV-1 Infection | Homo sapiens | National Institute of Environmental Health Sciences | MS* | 2025-10-12 | 1 | 238 | Uploaded data (56G)* |
