Summary of project PR002658
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002658. The data can be accessed directly via it's Project DOI: 10.21228/M82V85 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002658 |
| Project DOI: | doi: 10.21228/M82V85 |
| Project Title: | Paracrine stimulation of brown adipose tissue vascularization by adipocyte O-GlcNAc signaling |
| Project Summary: | Brown adipose tissue (BAT) is extensively vascularized, which is essential for its physiological activities. The molecular mechanism that underpins BAT vascularization, however, remains poorly understood. This study presents evidence that acute cold exposure induces an elevation in total protein O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) in BAT. Ablation of O-GlcNAc transferase in brown adipocytes drastically impairs BAT vascularization. Mechanistic studies demonstrate that O-GlcNAcylation of specificity protein 1 (SP1) in brown adipocytes enhances its transcriptional activity towards kielin/chordin-like protein (Kcp). Secreted KCP subsequently promotes BAT angiogenesis by paracrine activation of BMP signaling. Furthermore, boosting O-GlcNAc signaling with glucosamine supplementation effectively augments BAT vascularization and thermogenesis. These findings thus uncover a previously unrecognized role of adipocyte O-GlcNAc signaling in the metabolism-driven regulation of BAT vascularization and function. |
| Institute: | Shandong University |
| Last Name: | Li |
| First Name: | Luwen |
| Address: | Shandong University Baotuquan Campus, Baotuquan Subdistrict, Lixia District, Jinan City, Shandong Province, China, JiNan, Shandong, 250012, China |
| Email: | liluwenchina@outlook.com |
| Phone: | 18766179319 |
Summary of all studies in project PR002658
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004216 | Paracrine stimulation of brown adipose tissue vascularization by adipocyte O-GlcNAc signaling | Mus musculus | Shandong University | MS | 2025-12-22 | 1 | 8 | Uploaded data (2G)* |
