Summary of project PR002675
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002675. The data can be accessed directly via it's Project DOI: 10.21228/M8W83V This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002675 |
| Project DOI: | doi: 10.21228/M8W83V |
| Project Title: | Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus |
| Project Summary: | This study aimed to understand the impact of 2-deoxy-D-glucose (2DG) in modulating the transcriptional and metabolomic responses of T follicular helper cells (Tfh) in a lupus-prone mouse model (W.Yaa). Thus, we analyzed the metabolomes of Tfh cells purified the spleen of W.Yaa mice treated with 2DG versus untreated controls. Data demonstrated that inhibition of glycolysis via 2DG treatment profoundly reprogrammed the metabolic pathways of splenic Tfh cells. This includes the suppression of the pentose phosphate pathway, essential for autoimmune Tfh cell expansion and the activation of mitochondrial metabolism. The reprogrammed metabolism of Tfh cells was associated with the reduction of autoantibodies and autoimmune phenotype. |
| Institute: | UT Health San Antonio |
| Department: | Microbiology, Immunology. Molecular Genetics |
| Last Name: | Yong |
| First Name: | Ge |
| Address: | 7703 Flyod Curl Dr |
| Email: | geyong725@gmail.com |
| Phone: | 210-567-3925 |
| Funding Source: | NIH |
| Publications: | Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus |
Summary of all studies in project PR002675
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004242 | Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus - lupus prone W.Yaa mouse treated with 2-deoxy-D-glucose | Mus musculus | UT Health San Antonio | MS* | 2025-10-02 | 1 | 20 | Uploaded data (1.1G)* |
| ST004243 | Glycolysis inhibition functionally reprograms T follicular helper cells and reverses lupus - human Lupus patients | Homo sapiens | UT Health San Antonio | MS* | 2025-10-02 | 1 | 6 | Uploaded data (320.7M)* |
