Summary of project PR002684
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002684. The data can be accessed directly via it's Project DOI: 10.21228/M8QG20 This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002684 |
| Project DOI: | doi: 10.21228/M8QG20 |
| Project Title: | Central carbon metabolites in Wild Type (WT) and dioxin response element (DRE) mice |
| Project Type: | Targeted MS |
| Project Summary: | Central carbon metabolite changes were assessed in WT and PkmΔDRE mice treated with 30 µg/kg TCDD every 4 day for 28 days. Metabolomic analysis also revealed differences in glycolytic, TCA cycle and pentose phosphate pathway metabolite levels in TCDD treated WT and PkmΔDRE liver extracts. In addition, amino acid metabolism and serine/glycine synthesis were also elevated, especially in PkmΔDRE. These findings indicate PKM2 induction affects the transcriptional and metabolic coordination of hepatic responses to TCDD. |
| Institute: | Michigan State University |
| Last Name: | Orlowska |
| First Name: | Karina |
| Address: | 1129 Farm Lane, Room 248, East Lansing, Michigan, 48824, USA |
| Email: | orlowska@msu.edu |
| Phone: | 5178842054 |
Summary of all studies in project PR002684
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004256 | Central carbon metabolites in Wild Type (WT) and dioxin response element (DRE) mice treated with TCDD | Mus musculus | Michigan State University | MS | 2025-10-10 | 1 | 20 | Uploaded data (3.5G)* |
