Summary of project PR002687
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002687. The data can be accessed directly via it's Project DOI: 10.21228/M8B85N This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002687 |
| Project DOI: | doi: 10.21228/M8B85N |
| Project Title: | Phytate enhances gut Parasutterella colonization to alleviate radiation injury via anti-inflammatory and antioxidant effects |
| Project Summary: | Food as medicine shows promise for disease intervention or treatment. Here, we found phytate, an active ingredient of plant-based diets, exhibits properties in mitigating radiotherapy-related complications. Oral gavage of phytate restored hematogenic organ atrophy, elevated peripheral blood neutrophils and white blood cells, reduced inflammation, and improved gastrointestinal (GI) integrity in irradiated mice. Phytate intake modulated the gut microbiota, facilitating the colonization of symbiotic Parasutterella in GI tract, thus combating intestinal radiation toxicity. In vitro assays and untargeted metabolomics identified 3-Phenyllactic acid (PLA) and N-Acetyl-L-leucine (NL) as functional metabolites produced by Parasutterella. In vitro, ex vivo, and in vivo models showed that PLA induces M2-like polarization in macrophages, while NL reduced oxidative stress, both counteracting radiation toxicity and working synergistically. Our findings offer mechanistic insights into phytate for alleviating radiation-associated complications and suggest that Parasutterella and its metabolites might be employed as promising probiotics or postbiotics for cancer patients with radiotherapy. |
| Institute: | Chinese Academy of Medical Sciences |
| Last Name: | Li |
| First Name: | Yuan |
| Address: | Baidi Road, Tianjin, Tianjin, 300192, China |
| Email: | liyuan@irm-cams.ac.cn |
| Phone: | +8615900383739 |
Summary of all studies in project PR002687
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004259 | Phytate enhances gut Parasutterella colonization to alleviate radiation injury via anti-inflammatory and antioxidant effects | Homo sapiens | Chinese Academy of Medical Sciences | MS* | 2025-10-28 | 1 | 18 | Uploaded data (4.3G)* |
