Summary of project PR002702
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002702. The data can be accessed directly via it's Project DOI: 10.21228/M8D27Z This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002702 |
| Project DOI: | doi: 10.21228/M8D27Z |
| Project Title: | Global metabolomics identifies new extracellular biomarkers of nanovibration-driven mesenchymal stem cells osteodifferentiation |
| Project Summary: | Bone-related conditions are a leading cause of disability and rising healthcare costs, prompting interest in tissue engineering solutions using mesenchymal stem cells (MSC). As part of an effort to eliminate synthetic osteogenic compounds, this study characterizes the metabolic adaptations of MSC to chemical-free nanovibration (or nanokicking, NK)-induced osteodifferentiation. Through articulation of conventional gene markers and a global metabolomics/lipidomics strategy, our findings indicate successful slow-paced osteodifferentiation, expressed by subtle and partially reversible intracellular changes, and pronounced, largely irreversible, extracellular alterations. |
| Institute: | University of Aveiro |
| Department: | Chemistry |
| Laboratory: | CICECO - Aveiro Institute of Materials |
| Last Name: | Gil |
| First Name: | Ana M. |
| Address: | CICECO, Departamento de química, Campus de Santiago, Aveiro, Portugal |
| Email: | agil@ua.pt |
| Phone: | +351 234 370 707 |
| Funding Source: | This work was developed within the scope of the CICECO-Aveiro Institute of Materials, UIDB/50011/2020 project (doi: 10.54499/UIDB/50011/2020), UIDP/50011/2020 (doi: 10.54499/UIDP/ 50011/2020) and LA/P/0006/2020 (doi:10.54499/LA/P/0006/2020), financed by national funds through the FCT/MCTES (PIDDAC). We acknowledge funds from the Foundation for Science and Technology through the BetterBone project (2022.04286.PTDC, doi: 10.54499/2022.04286.PTDC), the Portuguese National NMR Network (RNRMN), supported by Infrastructure Project Nº 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC); and FCT/SPQ PhD grant (DSCB) (SFRH/BD/150655/2020, doi: 10.54499/SFRH/BD/150655/2020). EPSRC grant EP/P001114/1. |
Summary of all studies in project PR002702
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004276 | (NMR data) Global metabolomics identifies new extracellular biomarkers of nanovibration-driven mesenchymal stem cells osteodifferentiation | Homo sapiens | University of Aveiro | NMR | 2025-10-18 | 1 | 51 | Uploaded data (75.5M)* |
| ST004296 | (MS data) Global metabolomics identifies new extracellular biomarkers of nanovibration-driven mesenchymal stem cells osteodifferentiation | Homo sapiens | University of Aveiro | MS | 2025-10-18 | 1 | 15 | Not available |
