Summary of project PR002735
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002735. The data can be accessed directly via it's Project DOI: 10.21228/M84G1B This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002735 |
| Project DOI: | doi: 10.21228/M84G1B |
| Project Title: | Metabolomics study on mouse serum in the context of cancer cachexia with food intake control |
| Project Type: | Untargeted metabolomics |
| Project Summary: | Cancer cachexia is characterized by involuntary weight loss and wasting of fat and muscle tissues, with diminished food intake due to anorexia commonly cited as a cause. However, to what extent reduced food intake drives these symptoms and other cachexia phenotypes, such as fatigue and metabolism, remains generally unclear in preclinical models and patient populations.. Here, we demonstrate the critical need to address this question in cancer cachexia research. Using the colon carcinoma 26 (C26) mouse model, we assessed the role of food intake in key cachexia phenotypes. We found that reduced food intake was the predominant driver of body weight loss and wasting of fat and muscle, suggesting no additional causal mechanisms. In contrast, food intake reduction did not affect physical performance, indicating food intake-independent factors in causing fatigue. We found that cancer cachexia in the C26 mouse model is accompanied by widespread metabolic reprogramming, particularly affecting glucose, fatty acid, and amino acid metabolism. Thus, depending on the model or patient group, reduced food intake may primarily drive some cachectic phenotypes while having no role in others. Discriminating between food intake-mediated effects and those independent of it is critical for guiding research focus and unraveling the causal pathways of cancer cachexia. |
| Institute: | Harvard School of Public Health |
| Department: | Department of Molecular Metabolism |
| Laboratory: | Hui Lab |
| Last Name: | Yanshan |
| First Name: | Liang |
| Address: | 655 Huntington Ave Room 133, Boston, MA, 02115, USA |
| Email: | yliang@hsph.harvard.edu |
| Phone: | 8578321174 |
| Funding Source: | NCI and Cancer Research UK |
Summary of all studies in project PR002735
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004321 | Food intake-independent metabolic alterations in cachectic C26 mice compared to non-cachectic C26 mice | Mus musculus | Harvard School of Public Health | MS | 2025-11-19 | 1 | 33 | Uploaded data (2.9G)* |
