Summary of project PR002739
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002739. The data can be accessed directly via it's Project DOI: 10.21228/M8MG1P This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
| Project ID: | PR002739 |
| Project DOI: | doi: 10.21228/M8MG1P |
| Project Title: | Dynamics of urine metabolomics and tubular inflammatory cytokines in Type 1 diabetes across disease durations |
| Project Summary: | Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by sustained inflammation, leading to diabetic kidney disease (DKD). This study investigated urinary tubular injury biomarkers and metabolomic profiles in relation to albuminuria and renal function across varying durations of T1D. Urinary cytokines (MCP-1, KIM-1, NGAL) were measured by ELISA, and metabolomic profiling was performed using ^1H-NMR spectroscopy. Distinct urinary signatures were identified across T1D duration, including progressive increases in N-acetylcysteine (NAC) and N-delta-acetylornithine (NAO), with decreases in N-acetylaspartate (NAA) and pyruvic acid. These findings suggest early biomarkers of subclinical kidney dysfunction and potential metabolic disturbances associated with T1D progression. |
| Institute: | Lin-Kou Chang Gung Memorial hospital |
| Department: | Pediatric Nephrology |
| Last Name: | Yu |
| First Name: | Mei-Ching |
| Address: | No. 5, Fuxing St., Guishan Dist., Taoyuan, Taiwan |
| Email: | mc.yu@cgmh.org.tw |
| Phone: | +886 3281200 Ext 8202 |
Summary of all studies in project PR002739
| Study ID | Study Title | Species | Institute | Analysis(* : Contains Untargted data) | Release Date | Version | Samples | Download(* : Contains raw data) |
|---|---|---|---|---|---|---|---|---|
| ST004325 | Dynamics of urine metabolomics and tubular inflammatory cytokines in Type 1 diabetes across disease durations | Homo sapiens | Lin-Kou Chang Gung Memorial hospital | NMR | 2025-11-21 | 1 | 247 | Uploaded data (227.8M)* |
