Summary of project PR002792

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR002792. The data can be accessed directly via it's Project DOI: 10.21228/M8RV8C This work is supported by NIH grant, U2C- DK119886. See: https://www.metabolomicsworkbench.org/about/howtocite.php

Project ID: PR002792
Project DOI:doi: 10.21228/M8RV8C
Project Title:Lipidomic analysis of iPSC-derived microglia models
Project Summary:Altered microglial lipid metabolism is heavily implicated in Alzheimer’s disease (AD) and ageing. Recently, protocols were developed to generate human induced pluripotent stem cell-derived microglia-like cells (iMGL) to study microglial function in vitro, including embryoid body-based methods and transcription factor-dependent (iTF) approaches. Here, we performed comparative lipidomics on iMGL from these methods and report major differences in multiple lipid classes including triglycerides (TG), a storage form of fatty acids implicated in microglial reactivity. We compared the lipid composition of iPSC-derived microglia generated using a classical EB-based method and an iTF-based method.
Institute:VU Amsterdam
Department:Department of Functional Genomics, CNCR
Laboratory:Dementia discovery group
Last Name:van der Kant
First Name:Rik
Address:De Boelelaan 1100, Amsterdam, North-Holland, 1081HZ, Netherlands
Email:r.h.n.vander.kant@vu.nl
Phone:+31205981809

Summary of all studies in project PR002792

Study IDStudy TitleSpeciesInstituteAnalysis
(* : Contains Untargted data)		 Release
Date		VersionSamplesDownload
(* : Contains raw data)
ST004421 Comparative lipidomics of iPSC-derived microglia protocols reveal lipid droplet and immune differences mediated by media composition Homo sapiens VU Amsterdam MS 2026-01-08 1 212 Uploaded data (42.6M)*
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