Summary of Study ST000250

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000202. The data can be accessed directly via it's Project DOI: 10.21228/M88W23 This work is supported by NIH grant, U2C- DK119886.

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Study IDST000250
Study TitleThe Role of Obesity and Adipocytes in Immune Activation on Antiretroviral Therapy
Study TypeObservational, no intervention
Study SummaryCross-sectional, three arms
Institute
University of Florida
DepartmentSECIM
Last NameKoethe
First NameJohn
AddressA2200-MCN, 1161 21st Ave South, Nashville, TN 37232-2582
Emailjohn.r.koethe@vanderbilt.edu
Phone615-343-0533
Submit Date2015-01-07
Num Groups3
Total Subjects100 patients, one sample per patient
Raw Data AvailableNo
Raw Data File Type(s)raw(Thermo), d
Analysis Type DetailLC-MS
Release Date2016-12-22
Release Version1
John Koethe John Koethe
https://dx.doi.org/10.21228/M88W23
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR000202
Project DOI:doi: 10.21228/M88W23
Project Title:The Role of Obesity and Adipocytes in Immune Activation on Antiretroviral Therapy
Project Type:Clinical research
Project Summary:The goal of this study is the use metabolomics to probe the role of BCAA metabolism in the apthogenisis of insulin-resistance associated with HIV-infection/ART. We will also quantify the plasma levels of 2-HBA in HIV-infected, ART -treated patients. These patients were substratified into obese or lean subjects
Institute:Vanderbilt University
Department:Division of Infectious Diseases
Last Name:Koethe
First Name:John
Address:A2200-MCN, 1161 21st Ave South, Nashville, TN 37232-2582
Email:john.r.koethe@vanderbilt.edu
Phone:615-343-0533
Funding Source:National Institute of Allergy and Infectious Diseases

Subject:

Subject ID:SU000270
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Species Group:Human

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id HIV status
SA011390523negative | Obesity:Yes | Sex:F | Race:B
SA011391524negative | Obesity:Yes | Sex:F | Race:B
SA011392520negative | Obesity:Yes | Sex:F | Race:B
SA011393516negative | Obesity:Yes | Sex:F | Race:B
SA011394509negative | Obesity:Yes | Sex:F | Race:B
SA011395515negative | Obesity:Yes | Sex:F | Race:B
SA011396527negative | Obesity:Yes | Sex:F | Race:B
SA011397517negative | Obesity:Yes | Sex:F | Race:B
SA011398514negative | Obesity:Yes | Sex:F | Race:W
SA011399513negative | Obesity:Yes | Sex:F | Race:W
SA011400505negative | Obesity:Yes | Sex:F | Race:W
SA011401502negative | Obesity:Yes | Sex:F | Race:W
SA011402534negative | Obesity:Yes | Sex:F | Race:W
SA011403533negative | Obesity:Yes | Sex:F | Race:W
SA011404521negative | Obesity:Yes | Sex:F | Race:W
SA011405525negative | Obesity:Yes | Sex:F | Race:W
SA011406503negative | Obesity:Yes | Sex:F | Race:W
SA011407501negative | Obesity:Yes | Sex:F | Race:W
SA011408512negative | Obesity:Yes | Sex:M | Race:B
SA011409528negative | Obesity:Yes | Sex:M | Race:B
SA011410531negative | Obesity:Yes | Sex:M | Race:B
SA011411507negative | Obesity:Yes | Sex:M | Race:B
SA011412510negative | Obesity:Yes | Sex:M | Race:W
SA011413506negative | Obesity:Yes | Sex:M | Race:W
SA011414511negative | Obesity:Yes | Sex:M | Race:W
SA011415508negative | Obesity:Yes | Sex:M | Race:W
SA011416519negative | Obesity:Yes | Sex:M | Race:W
SA011417518negative | Obesity:Yes | Sex:M | Race:W
SA011418530negative | Obesity:Yes | Sex:M | Race:W
SA011419532negative | Obesity:Yes | Sex:M | Race:W
SA01142042positive | Obesity:No | Sex:F | Race:B
SA0114213positive | Obesity:No | Sex:F | Race:B
SA01142241positive | Obesity:No | Sex:F | Race:B
SA01142371positive | Obesity:No | Sex:F | Race:B
SA01142423positive | Obesity:No | Sex:F | Race:B
SA01142558positive | Obesity:No | Sex:F | Race:B
SA01142624positive | Obesity:No | Sex:F | Race:B
SA01142733positive | Obesity:No | Sex:F | Race:B
SA01142834positive | Obesity:No | Sex:F | Race:B
SA01142937positive | Obesity:No | Sex:F | Race:B
SA01143060positive | Obesity:No | Sex:F | Race:W
SA01143155positive | Obesity:No | Sex:F | Race:W
SA01143261positive | Obesity:No | Sex:F | Race:W
SA01143343positive | Obesity:No | Sex:F | Race:W
SA01143430positive | Obesity:No | Sex:M | Race:B
SA01143513positive | Obesity:No | Sex:M | Race:B
SA01143635positive | Obesity:No | Sex:M | Race:B
SA01143714positive | Obesity:No | Sex:M | Race:B
SA0114384positive | Obesity:No | Sex:M | Race:B
SA01143927positive | Obesity:No | Sex:M | Race:B
SA0114401positive | Obesity:No | Sex:M | Race:O
SA01144167positive | Obesity:No | Sex:M | Race:W
SA01144257positive | Obesity:No | Sex:M | Race:W
SA01144316positive | Obesity:No | Sex:M | Race:W
SA01144454positive | Obesity:No | Sex:M | Race:W
SA0114458positive | Obesity:No | Sex:M | Race:W
SA01144636positive | Obesity:No | Sex:M | Race:W
SA0114477positive | Obesity:No | Sex:M | Race:W
SA01144826positive | Obesity:No | Sex:M | Race:W
SA0114496positive | Obesity:No | Sex:M | Race:W
SA01145031positive | Obesity:No | Sex:M | Race:W
SA0114515positive | Obesity:No | Sex:M | Race:W
SA01145217positive | Obesity:Yes | Sex:F | Race:B
SA01145320positive | Obesity:Yes | Sex:F | Race:B
SA01145432positive | Obesity:Yes | Sex:F | Race:B
SA01145525positive | Obesity:Yes | Sex:F | Race:B
SA01145674positive | Obesity:Yes | Sex:F | Race:B
SA01145756positive | Obesity:Yes | Sex:F | Race:B
SA01145864positive | Obesity:Yes | Sex:F | Race:B
SA01145969positive | Obesity:Yes | Sex:F | Race:B
SA01146077positive | Obesity:Yes | Sex:F | Race:B
SA01146115positive | Obesity:Yes | Sex:F | Race:B
SA01146210positive | Obesity:Yes | Sex:F | Race:B
SA01146362positive | Obesity:Yes | Sex:F | Race:B
SA01146422positive | Obesity:Yes | Sex:F | Race:W
SA01146545positive | Obesity:Yes | Sex:F | Race:W
SA01146652positive | Obesity:Yes | Sex:F | Race:W
SA01146766positive | Obesity:Yes | Sex:F | Race:W
SA01146812positive | Obesity:Yes | Sex:M | Race:B
SA01146948positive | Obesity:Yes | Sex:M | Race:B
SA01147065positive | Obesity:Yes | Sex:M | Race:B
SA01147144positive | Obesity:Yes | Sex:M | Race:B
SA01147239positive | Obesity:Yes | Sex:M | Race:B
SA01147363positive | Obesity:Yes | Sex:M | Race:B
SA01147476positive | Obesity:Yes | Sex:M | Race:O
SA01147575positive | Obesity:Yes | Sex:M | Race:O
SA01147680positive | Obesity:Yes | Sex:M | Race:O
SA01147772positive | Obesity:Yes | Sex:M | Race:W
SA0114789positive | Obesity:Yes | Sex:M | Race:W
SA01147947positive | Obesity:Yes | Sex:M | Race:W
SA01148046positive | Obesity:Yes | Sex:M | Race:W
SA01148140positive | Obesity:Yes | Sex:M | Race:W
SA01148228positive | Obesity:Yes | Sex:M | Race:W
SA01148311positive | Obesity:Yes | Sex:M | Race:W
SA01148479positive | Obesity:Yes | Sex:M | Race:W
SA01148519positive | Obesity:Yes | Sex:M | Race:W
SA01148678positive | Obesity:Yes | Sex:M | Race:W
SA01148750positive | Obesity:Yes | Sex:M | Race:W
SA01148849positive | Obesity:Yes | Sex:M | Race:W
SA01148959positive | Obesity:Yes | Sex:M | Race:W
Showing results 1 to 100 of 100

Collection:

Collection ID:CO000261
Collection Summary:-
Collection Protocol Filename:Koethe_SECIM_collection.txt
Sample Type:Blood

Treatment:

Treatment ID:TR000281
Treatment Protocol Filename:Koethe_SECIM_treatments.txt

Sample Preparation:

Sampleprep ID:SP000275
Sampleprep Summary:Amino acid|Organic acid|Acylcarnitines
Sampleprep Protocol Filename:SB_AA_Assay.pdf
SB_OA_Assay.pdf
SB_Acylcarnitine_Assay.pdf

Combined analysis:

Analysis ID AN000394 AN000395 AN000396
Analysis type MS MS MS
Chromatography type Reversed phase Reversed phase Reversed phase
Chromatography system Agilent 1290 Infinity Thermo Dionex Ultimate 3000 Agilent 1290 Infinity
Column Waters AccQ Tag (100 x 2mm,1.7um) Waters Acquity BEH C18 (100 x 2mm,1.7um) Waters Acquity BEH C18 (100 x 2mm,1.7um)
MS Type ESI ESI ESI
MS instrument type Triple quadrupole Triple quadrupole Triple quadrupole
MS instrument name Agilent 6490 QQQ Thermo Quantiva QQQ Agilent 6490 QQQ
Ion Mode POSITIVE POSITIVE POSITIVE
Units uM uM

Chromatography:

Chromatography ID:CH001335
Methods Filename:SB_AA_Assay.pdf
Instrument Name:Agilent 1290 Infinity
Column Name:Waters AccQ Tag (100 x 2mm,1.7um)
Column Temperature:55
Flow Rate:0.7 mL/min
Solvent A:AccQ·Tag Eluent A
Solvent B:accQ·Tag Eluent B
Chromatography Type:Reversed phase
  
Chromatography ID:CH001336
Methods Filename:SB_OA_Assay.pdf
Instrument Name:Thermo Dionex Ultimate 3000
Column Name:Waters Acquity BEH C18 (100 x 2mm,1.7um)
Column Temperature:45
Flow Rate:0.3 mL/min
Solvent A:100% water; 0.1% formic acid
Solvent B:100% acetonitrile; 0.1% formic acid
Chromatography Type:Reversed phase
  
Chromatography ID:CH001337
Methods Filename:SB_Acylcarnitine_Assay.pdf
Instrument Name:Agilent 1290 Infinity
Column Name:Waters Acquity BEH C18 (100 x 2mm,1.7um)
Chromatography Type:Reversed phase

MS:

MS ID:MS000338
Analysis ID:AN000394
Instrument Name:Agilent 6490 QQQ
Instrument Type:Triple quadrupole
MS Type:ESI
MS Comments:POSITIVE
Ion Mode:POSITIVE
  
MS ID:MS000339
Analysis ID:AN000395
Instrument Name:Thermo Quantiva QQQ
Instrument Type:Triple quadrupole
MS Type:ESI
MS Comments:POSITIVE
Ion Mode:POSITIVE
  
MS ID:MS000340
Analysis ID:AN000396
Instrument Name:Agilent 6490 QQQ
Instrument Type:Triple quadrupole
MS Type:ESI
MS Comments:POSITIVE
Ion Mode:POSITIVE
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