Summary of Study ST001322

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000899. The data can be accessed directly via it's Project DOI: 10.21228/M8GQ40 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001322
Study TitleMaternal adiposity alters the human milk metabolome: a link between non-glucose monosaccharides and infant adiposity
Study Typeuntargeted metabolomics
Study SummaryAn untargeted metabolomics analysis of human milk was performed to test the hypothesis that a unique human milk metabolome would emerge based on maternal adiposity (maternal fat mass and body mass index). This study also aimed to identify differentially expressed milk metabolites that are associated with fat mass in the infant. To our knowledge this study reports on the largest cohort to date examining the metabolomic differences in human milk composition between normal weight and obese women. Data generated from this study indicate the need for further research in the area of human milk metabolomics and the potential role for human milk small molecules in contributing to offspring growth and development.
Institute
University of California, Davis
DepartmentWest Coast Metabolomics Center
Last NamePaglia
First NameKelly
Address451 Health Sciences Drive, Room 1313, Davis, CA, 95616, USA
Emailkpaglia@ucdavis.edu
Phone5307528129
Submit Date2020-02-25
Raw Data AvailableYes
Raw Data File Type(s)cdf
Analysis Type DetailGC-MS
Release Date2020-03-17
Release Version1
Kelly Paglia Kelly Paglia
https://dx.doi.org/10.21228/M8GQ40
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR000899
Project DOI:doi: 10.21228/M8GQ40
Project Title:Maternal adiposity alters the human milk metabolome: a link between non-glucose monosaccharides and infant adiposity
Project Type:metabolomics
Project Summary:An untargeted metabolomics analysis of human milk was performed to test the hypothesis that a unique human milk metabolome would emerge based on maternal adiposity (maternal fat mass and body mass index). This study also aimed to identify differentially expressed milk metabolites that are associated with fat mass in the infant. To our knowledge this study reports on the largest cohort to date examining the metabolomic differences in human milk composition between normal weight and obese women. Data generated from this study indicate the need for further research in the area of human milk metabolomics and the potential role for human milk small molecules in contributing to offspring growth and development.
Institute:University of California, Davis
Department:West Coast Metabolomics Center
Last Name:Paglia
First Name:Kelly
Address:451 Health Sciences Drive, Room 1313, Davis, CA, 95616, USA
Email:kpaglia@ucdavis.edu
Phone:5307528129

Subject:

Subject ID:SU001396
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id treatment
SA095582ex-173_354expecting 2 month - human breast milk | group:OB
SA095583ex-175_355expecting 2 month - human breast milk | group:OB
SA095584ex-181_357expecting 2 month - human breast milk | group:OB
SA095585ex-172_353expecting 2 month - human breast milk | group:OB
SA095586ex-177_356expecting 2 month - human breast milk | group:OB
SA095587ex-168_351expecting 2 month - human breast milk | group:OB
SA095588ex-163_348expecting 2 month - human breast milk | group:OB
SA095589ex-164_349expecting 2 month - human breast milk | group:OB
SA095590ex-166_350expecting 2 month - human breast milk | group:OB
SA095591ex-183_358expecting 2 month - human breast milk | group:OB
SA095592ex-171_352expecting 2 month - human breast milk | group:OB
SA095593ex-186_360expecting 2 month - human breast milk | group:OB
SA095594ex-200_367expecting 2 month - human breast milk | group:OB
SA095595ex-201_368expecting 2 month - human breast milk | group:OB
SA095596ex-202_369expecting 2 month - human breast milk | group:OB
SA095597ex-103_323expecting 2 month - human breast milk | group:OB
SA095598ex-199_366expecting 2 month - human breast milk | group:OB
SA095599ex-194_365expecting 2 month - human breast milk | group:OB
SA095600ex-161_347expecting 2 month - human breast milk | group:OB
SA095601ex-191_362expecting 2 month - human breast milk | group:OB
SA095602ex-192_363expecting 2 month - human breast milk | group:OB
SA095603ex-193_364expecting 2 month - human breast milk | group:OB
SA095604ex-184_359expecting 2 month - human breast milk | group:OB
SA095605ex-187_361expecting 2 month - human breast milk | group:OB
SA095606ex-116_330expecting 2 month - human breast milk | group:OB
SA095607ex-117_331expecting 2 month - human breast milk | group:OB
SA095608ex-119_332expecting 2 month - human breast milk | group:OB
SA095609ex-120_333expecting 2 month - human breast milk | group:OB
SA095610ex-109_328expecting 2 month - human breast milk | group:OB
SA095611ex-108_327expecting 2 month - human breast milk | group:OB
SA095612ex-156_346expecting 2 month - human breast milk | group:OB
SA095613ex-104_324expecting 2 month - human breast milk | group:OB
SA095614ex-106_325expecting 2 month - human breast milk | group:OB
SA095615ex-107_326expecting 2 month - human breast milk | group:OB
SA095616ex-123_334expecting 2 month - human breast milk | group:OB
SA095617ex-115_329expecting 2 month - human breast milk | group:OB
SA095618ex-146_343expecting 2 month - human breast milk | group:OB
SA095619ex-142_342expecting 2 month - human breast milk | group:OB
SA095620ex-147_344expecting 2 month - human breast milk | group:OB
SA095621ex-127_335expecting 2 month - human breast milk | group:OB
SA095622ex-154_345expecting 2 month - human breast milk | group:OB
SA095623ex-135_340expecting 2 month - human breast milk | group:OB
SA095624ex-137_341expecting 2 month - human breast milk | group:OB
SA095625ex-129_337expecting 2 month - human breast milk | group:OB
SA095626ex-130_338expecting 2 month - human breast milk | group:OB
SA095627ex-128_336expecting 2 month - human breast milk | group:OB
SA095628ex-134_339expecting 2 month - human breast milk | group:OB
SA095629ex-168_303expecting 2 week - human breast milk | group:OB
SA095630ex-167_302expecting 2 week - human breast milk | group:OB
SA095631ex-173_304expecting 2 week - human breast milk | group:OB
SA095632ex-181_307expecting 2 week - human breast milk | group:OB
SA095633ex-163_300expecting 2 week - human breast milk | group:OB
SA095634ex-177_306expecting 2 week - human breast milk | group:OB
SA095635ex-175_305expecting 2 week - human breast milk | group:OB
SA095636ex-154_295expecting 2 week - human breast milk | group:OB
SA095637ex-182_308expecting 2 week - human breast milk | group:OB
SA095638ex-153_294expecting 2 week - human breast milk | group:OB
SA095639ex-155_296expecting 2 week - human breast milk | group:OB
SA095640ex-156_297expecting 2 week - human breast milk | group:OB
SA095641ex-157_298expecting 2 week - human breast milk | group:OB
SA095642ex-161_299expecting 2 week - human breast milk | group:OB
SA095643ex-202_321expecting 2 week - human breast milk | group:OB
SA095644ex-199_318expecting 2 week - human breast milk | group:OB
SA095645ex-197_317expecting 2 week - human breast milk | group:OB
SA095646ex-200_319expecting 2 week - human breast milk | group:OB
SA095647ex-201_320expecting 2 week - human breast milk | group:OB
SA095648ex-152_293expecting 2 week - human breast milk | group:OB
SA095649ex-204_322expecting 2 week - human breast milk | group:OB
SA095650ex-195_316expecting 2 week - human breast milk | group:OB
SA095651ex-194_315expecting 2 week - human breast milk | group:OB
SA095652ex-187_311expecting 2 week - human breast milk | group:OB
SA095653ex-184_310expecting 2 week - human breast milk | group:OB
SA095654ex-191_312expecting 2 week - human breast milk | group:OB
SA095655ex-192_313expecting 2 week - human breast milk | group:OB
SA095656ex-193_314expecting 2 week - human breast milk | group:OB
SA095657ex-183_309expecting 2 week - human breast milk | group:OB
SA095658ex-166_301expecting 2 week - human breast milk | group:OB
SA095659ex-119_273expecting 2 week - human breast milk | group:OB
SA095660ex-116_271expecting 2 week - human breast milk | group:OB
SA095661ex-120_274expecting 2 week - human breast milk | group:OB
SA095662ex-121_275expecting 2 week - human breast milk | group:OB
SA095663ex-127_277expecting 2 week - human breast milk | group:OB
SA095664ex-123_276expecting 2 week - human breast milk | group:OB
SA095665ex-115_270expecting 2 week - human breast milk | group:OB
SA095666ex-114_269expecting 2 week - human breast milk | group:OB
SA095667ex-104_264expecting 2 week - human breast milk | group:OB
SA095668ex-151_292expecting 2 week - human breast milk | group:OB
SA095669ex-106_265expecting 2 week - human breast milk | group:OB
SA095670ex-107_266expecting 2 week - human breast milk | group:OB
SA095671ex-109_268expecting 2 week - human breast milk | group:OB
SA095672ex-108_267expecting 2 week - human breast milk | group:OB
SA095673ex-128_278expecting 2 week - human breast milk | group:OB
SA095674ex-117_272expecting 2 week - human breast milk | group:OB
SA095675ex-142_287expecting 2 week - human breast milk | group:OB
SA095676ex-137_286expecting 2 week - human breast milk | group:OB
SA095677ex-144_288expecting 2 week - human breast milk | group:OB
SA095678ex-146_289expecting 2 week - human breast milk | group:OB
SA095679ex-150_291expecting 2 week - human breast milk | group:OB
SA095680ex-129_279expecting 2 week - human breast milk | group:OB
SA095681ex-103_263expecting 2 week - human breast milk | group:OB
Showing page 1 of 4     Results:    1  2  3  4  Next     Showing results 1 to 100 of 386

Collection:

Collection ID:CO001391
Collection Summary:The breast milk was frozen at -70C upon arrival. At a later date, the milk was thawed, aliquoted and refrozen at -70C until time for shipment.
Sample Type:Breast

Treatment:

Treatment ID:TR001411
Treatment Summary:There are 2 groups and 3 time points., At 2 weeks, there are 160 samples. At 2 months, there are 132 samples. At 6 months, there are 94 samples, There is breast milk from normal weight and obese mothers at each time point.

Sample Preparation:

Sampleprep ID:SP001404
Sampleprep Summary:The breast milk was frozen at -70C upon arrival. At a later date, the milk was thawed, aliquoted and refrozen at -70C until time for shipment.

Combined analysis:

Analysis ID AN002198
Analysis type MS
Chromatography type GC
Chromatography system Leco Pegasus IV GC
Column Restek Rtx-5Sil (30m x 0.25mm,0.25um)
MS Type EI
MS instrument type QTOF
MS instrument name Leco Pegasus IV TOF
Ion Mode POSITIVE
Units normalized peak height

Chromatography:

Chromatography ID:CH001612
Instrument Name:Leco Pegasus IV GC
Column Name:Restek Rtx-5Sil (30m x 0.25mm,0.25um)
Chromatography Type:GC

MS:

MS ID:MS002044
Analysis ID:AN002198
Instrument Name:Leco Pegasus IV TOF
Instrument Type:QTOF
MS Type:EI
MS Comments:A Leco Pegasus IV time of flight mass spectrometer is controlled by the Leco ChromaTOF software vs. 2.32 (St. Joseph, MI). The transfer line temperature between gas chromatograph and mass spectrometer is set to 280°C. Electron impact ionization at 70V is employed with an ion source temperature of 250°C. Acquisition rate is 17 spectra/second, with a scan mass range of 85-500 Da.
Ion Mode:POSITIVE
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