Summary of Study ST001728

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001107. The data can be accessed directly via it's Project DOI: 10.21228/M8MD78 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001728
Study TitleMetabolomics and metagenomics of metformin (Urine)
Study SummaryMetformin affects the gut microbiome and altered microbiota may contribute to the hypoglycemic effect of metformin. Metabolomic analysis can be useful to elucidate the potential underlying mechanisms of the hypoglycemic effect according to the change in the microbiome and metabolites induced by the administration of metformin.
Institute
Seoul National University
DepartmentDepartment of Clinical Pharmacology and Therapeutics, College of Medicine and Hospital
Last NameLee
First NameYujin
Address101 Daehak-ro, Jongno-gu, Seoul 110-799, Korea
Emailyoojinlee@snu.ac.kr
Phone+821033804686
Submit Date2021-03-16
Raw Data AvailableYes
Raw Data File Type(s)smp
Analysis Type DetailGC-MS
Release Date2021-08-31
Release Version1
Yujin Lee Yujin Lee
https://dx.doi.org/10.21228/M8MD78
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR001107
Project DOI:doi: 10.21228/M8MD78
Project Title:Metabolomics and metagenomics of metformin (Plasma)
Project Summary:Metformin affects the gut microbiome and altered microbiota may contribute to the hypoglycemic effect of metformin. Metabolomic analysis can be useful to elucidate the potential underlying mechanisms of the hypoglycemic effect according to the change in the microbiome and metabolites induced by the administration of metformin.
Institute:Seoul National University
Department:Department of Clinical Pharmacology and Therapeutics, College of Medicine and Hospital
Laboratory:Metabolomics analysis lab
Last Name:Lee
First Name:Yujin
Address:101 Daehak-ro, Jongno-gu, Seoul 110-799, Korea
Email:yoojinlee@snu.ac.kr
Phone:+821033804686

Subject:

Subject ID:SU001805
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Gender:Male

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Gender
SA162541R204-P1Male | Race:Asian | Group:Control
SA162542R202-P1Male | Race:Asian | Group:Control
SA162543R201-P1Male | Race:Asian | Group:Control
SA162544R205-P1Male | Race:Asian | Group:Control
SA162545R207-P1Male | Race:Asian | Group:Control
SA162546R101-P1Male | Race:Asian | Group:Control
SA162547R210-P1Male | Race:Asian | Group:Control
SA162548R114-P1Male | Race:Asian | Group:Control
SA162549R206-P1Male | Race:Asian | Group:Control
SA162550R203-P1Male | Race:Asian | Group:Control
SA162551R106-P1Male | Race:Asian | Group:Control
SA162552R105-P1Male | Race:Asian | Group:Control
SA162553R113-P1Male | Race:Asian | Group:Control
SA162554R102-P1Male | Race:Asian | Group:Control
SA162555R107-P1Male | Race:Asian | Group:Control
SA162556R103-P1Male | Race:Asian | Group:Control
SA162557R109-P1Male | Race:Asian | Group:Control
SA162558R112-P1Male | Race:Asian | Group:Control
SA162559R111-P1Male | Race:Asian | Group:Control
SA162560R110-P1Male | Race:Asian | Group:Control
SA162561R203-P2Male | Race:Asian | Group:Treated
SA162562R202-P2Male | Race:Asian | Group:Treated
SA162563R201-P2Male | Race:Asian | Group:Treated
SA162564R204-P2Male | Race:Asian | Group:Treated
SA162565R207-P2Male | Race:Asian | Group:Treated
SA162566R114-P2Male | Race:Asian | Group:Treated
SA162567R210-P2Male | Race:Asian | Group:Treated
SA162568R206-P2Male | Race:Asian | Group:Treated
SA162569R205-P2Male | Race:Asian | Group:Treated
SA162570R101-P2Male | Race:Asian | Group:Treated
SA162571R106-P2Male | Race:Asian | Group:Treated
SA162572R105-P2Male | Race:Asian | Group:Treated
SA162573R103-P2Male | Race:Asian | Group:Treated
SA162574R102-P2Male | Race:Asian | Group:Treated
SA162575R107-P2Male | Race:Asian | Group:Treated
SA162576R109-P2Male | Race:Asian | Group:Treated
SA162577R112-P2Male | Race:Asian | Group:Treated
SA162578R111-P2Male | Race:Asian | Group:Treated
SA162579R110-P2Male | Race:Asian | Group:Treated
SA162580R113-P2Male | Race:Asian | Group:Treated
Showing results 1 to 40 of 40

Collection:

Collection ID:CO001798
Collection Summary:We recruited and included 20 healthy adult male subgects
Sample Type:Urine

Treatment:

Treatment ID:TR001818
Treatment Summary:The subjects received oral metformin 1000mg twice daily.

Sample Preparation:

Sampleprep ID:SP001811
Sampleprep Summary:Samples were extracted twice.

Combined analysis:

Analysis ID AN002813
Analysis type MS
Chromatography type GC
Chromatography system Agilent 7890B
Column Restek Rtx-5Sil (30m x 0.25mm,0.25um)
MS Type EI
MS instrument type GC-TOF
MS instrument name Leco Pegasus HT TOF
Ion Mode NEGATIVE
Units intensity

Chromatography:

Chromatography ID:CH002078
Instrument Name:Agilent 7890B
Column Name:Restek Rtx-5Sil (30m x 0.25mm,0.25um)
Chromatography Type:GC

MS:

MS ID:MS002607
Analysis ID:AN002813
Instrument Name:Leco Pegasus HT TOF
Instrument Type:GC-TOF
MS Type:EI
MS Comments:Leco® ChromaTOF-GC Software v4.72.0.0
Ion Mode:NEGATIVE
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