Summary of Study ST001729

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001107. The data can be accessed directly via it's Project DOI: 10.21228/M8MD78 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001729
Study TitleMetabolomics and metagenomics of metformin (Stool)
Study SummaryMetformin affects the gut microbiome and altered microbiota may contribute to the hypoglycemic effect of metformin. Metabolomic analysis can be useful to elucidate the potential underlying mechanisms of the hypoglycemic effect according to the change in the microbiome and metabolites induced by the administration of metformin.
Institute
Seoul National University
DepartmentDepartment of Clinical Pharmacology and Therapeutics, College of Medicine and Hospital
Last NameLee
First NameYujin
Address101 Daehak-ro, Jongno-gu, Seoul 110-799, Korea
Emailyoojinlee@snu.ac.kr
Phone+821033804686
Submit Date2021-03-17
Raw Data AvailableYes
Raw Data File Type(s)smp
Analysis Type DetailGC-MS
Release Date2021-08-31
Release Version1
Yujin Lee Yujin Lee
https://dx.doi.org/10.21228/M8MD78
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR001107
Project DOI:doi: 10.21228/M8MD78
Project Title:Metabolomics and metagenomics of metformin (Plasma)
Project Summary:Metformin affects the gut microbiome and altered microbiota may contribute to the hypoglycemic effect of metformin. Metabolomic analysis can be useful to elucidate the potential underlying mechanisms of the hypoglycemic effect according to the change in the microbiome and metabolites induced by the administration of metformin.
Institute:Seoul National University
Department:Department of Clinical Pharmacology and Therapeutics, College of Medicine and Hospital
Laboratory:Metabolomics analysis lab
Last Name:Lee
First Name:Yujin
Address:101 Daehak-ro, Jongno-gu, Seoul 110-799, Korea
Email:yoojinlee@snu.ac.kr
Phone:+821033804686

Subject:

Subject ID:SU001806
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Gender:Male

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Gender
SA162581R204-P1Male | Race:Asian | Group:Control
SA162582R202-P1Male | Race:Asian | Group:Control
SA162583R201-P1Male | Race:Asian | Group:Control
SA162584R205-P1Male | Race:Asian | Group:Control
SA162585R207-P1Male | Race:Asian | Group:Control
SA162586R101-P1Male | Race:Asian | Group:Control
SA162587R210-P1Male | Race:Asian | Group:Control
SA162588R114-P1Male | Race:Asian | Group:Control
SA162589R206-P1Male | Race:Asian | Group:Control
SA162590R203-P1Male | Race:Asian | Group:Control
SA162591R106-P1Male | Race:Asian | Group:Control
SA162592R105-P1Male | Race:Asian | Group:Control
SA162593R113-P1Male | Race:Asian | Group:Control
SA162594R102-P1Male | Race:Asian | Group:Control
SA162595R107-P1Male | Race:Asian | Group:Control
SA162596R103-P1Male | Race:Asian | Group:Control
SA162597R109-P1Male | Race:Asian | Group:Control
SA162598R112-P1Male | Race:Asian | Group:Control
SA162599R111-P1Male | Race:Asian | Group:Control
SA162600R110-P1Male | Race:Asian | Group:Control
SA162601R203-P2Male | Race:Asian | Group:Treated
SA162602R202-P2Male | Race:Asian | Group:Treated
SA162603R201-P2Male | Race:Asian | Group:Treated
SA162604R204-P2Male | Race:Asian | Group:Treated
SA162605R207-P2Male | Race:Asian | Group:Treated
SA162606R114-P2Male | Race:Asian | Group:Treated
SA162607R210-P2Male | Race:Asian | Group:Treated
SA162608R206-P2Male | Race:Asian | Group:Treated
SA162609R205-P2Male | Race:Asian | Group:Treated
SA162610R101-P2Male | Race:Asian | Group:Treated
SA162611R106-P2Male | Race:Asian | Group:Treated
SA162612R105-P2Male | Race:Asian | Group:Treated
SA162613R103-P2Male | Race:Asian | Group:Treated
SA162614R102-P2Male | Race:Asian | Group:Treated
SA162615R107-P2Male | Race:Asian | Group:Treated
SA162616R109-P2Male | Race:Asian | Group:Treated
SA162617R112-P2Male | Race:Asian | Group:Treated
SA162618R111-P2Male | Race:Asian | Group:Treated
SA162619R110-P2Male | Race:Asian | Group:Treated
SA162620R113-P2Male | Race:Asian | Group:Treated
Showing results 1 to 40 of 40

Collection:

Collection ID:CO001799
Collection Summary:We recruited and included 20 healthy adult male subjects
Sample Type:Feces

Treatment:

Treatment ID:TR001819
Treatment Summary:The subjects received oral metformin 1000mg twice daily.

Sample Preparation:

Sampleprep ID:SP001812
Sampleprep Summary:Samples were extracted twice.

Combined analysis:

Analysis ID AN002814
Analysis type MS
Chromatography type GC
Chromatography system Agilent 7890B
Column Restek Rtx-5Sil (30m x 0.25mm,0.25um)
MS Type EI
MS instrument type GC-TOF
MS instrument name Leco Pegasus HT TOF
Ion Mode NEGATIVE
Units intensity

Chromatography:

Chromatography ID:CH002079
Instrument Name:Agilent 7890B
Column Name:Restek Rtx-5Sil (30m x 0.25mm,0.25um)
Chromatography Type:GC

MS:

MS ID:MS002608
Analysis ID:AN002814
Instrument Name:Leco Pegasus HT TOF
Instrument Type:GC-TOF
MS Type:EI
MS Comments:Leco Chroma TOF-GC Software v4.72.0.0
Ion Mode:NEGATIVE
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