Summary of study ST000022

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000021. The data can be accessed directly via it's Project DOI: 10.21228/M8K01J This work is supported by NIH grant, U2C- DK119886.


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Study IDST000022
Study TitleBiomarker Discovery in Knee Osteoarthritis (II)
Study TypeBiomarker Discovery in Knee Osteoarthritis
Study SummaryThis metabolomics pilot and feasibility (P & F) study was conducted to provide data to be used to gain a better understanding of metabolic alterations in people with knee osteoarthritis (OA) and to discover novel biomarkers of the disease. The goal of the metabolomics study was to determine if metabolic differences, detected by a comprehensive metabolomics analysis, can be used to distinguish people who will develop symptomatic knee OA from those who will not. For this metabolomics study, individuals participating in T1 or T1* with 5-year follow-up at T2 were selected. At T2 subjects were on average 68.1(9.12) years old with an average BMI of 31.4(7.01) with 32% men and one-third African American. All had weight-bearing posterior-anterior knee films obtained with the Synaflexer positioning device at both time points and read paired for Kellgren-Lawrence grade and minimum joint space. Urine samples (second morning void) collected from 36 overweight or obese participants in the JoCo at T1 or T1* were selected from two subgroups (a group that developed radiographic osteoarthritis (n=16) and an age, race, sex, and BMI matched group that did not develop osteoarthritis (n=20). Radiographic knee OA was defined as Kellgren-Lawrence grade 2-4 at T2 in a person with Kellgren-Lawrence grade 0 or 1 at T1 or T1*.
University of North Carolina
DepartmentSystems and Translational Sciences
LaboratorySumner Lab
Last NameSumner
First NameSusan
AddressEastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081
Submit Date2014-03-04
Num Groups2
Total Subjects36
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2018-08-27
Release Version1
Susan Sumner Susan Sumner application/zip

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Project ID:PR000021
Project DOI:doi: 10.21228/M8K01J
Project Title:Johnston County Osteoarthritis Project
Project Type:Longitudinal study
Project Summary:The Johnston County Osteoarthritis Project (JoCo) is a 20+ year ongoing, population-based, prospective cohort study of knee and hip OA designed to be representative of the civilian, non-institutionalized, African American or Caucasian population aged 45 years and older, who were residents of one of 6 townships in Johnston County NC for at least 1 year, and who were physically and mentally capable of completing the studys protocol. All participants had an initial home interview, a clinic examination with radiographs, and a subsequent second home interview. Approximately 3,200 individuals were recruited into the baseline evaluation between 1991 and 1997 (T0); the first follow up visit (T1) occurred from 1999-2004, and the second follow up visit (T2) from 2006-2010. Cohort enrichment (T1*) occurred from 2003-4, allowing new participants to be enrolled; the first follow up for these individuals was at T2. At T0, the sample was approximately 38% men and one-third African American. Between T0 and T1, radiographic knee OA, defined as Kellgren-Lawrence grade 2-4, developed in 12% of knees without knee OA at T0.
Institute:University of North Carolina at Chapel Hill
Department:Thurston Arthritis Research Center, Division of Rheumatology, Allergy, and Immunology
Laboratory:Jordan Laboratory
Last Name:Jordan
First Name:Joanne
Address:3300 Thurston Bldg., CB# 7280, Chapel Hill, NC 27599-7280
Funding Source:Center for Disease Control (CDC)