Summary of study ST000051

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000049. The data can be accessed directly via it's Project DOI: 10.21228/M8W88R This work is supported by NIH grant, U2C- DK119886.


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Study IDST000051
Study TitleFetal metabolomic signature of exposure to iAs during pregnancy
Study TypeMetabolomics
Study SummaryThis metabolomics pilot study was aimed to identify a fetal metabolomic signature of exposure to iAs during pregnancy. Fetal cord blood serum was collected immediately after delivery from a saline cleaned umbilical cord using an anticoagulant-free vacutainer tube, after clot formation the tube was centrifuged at 1200 rpm and the serum was collected and stored at -70°C. A subset of 50 cord serum samples were selected from the larger BEAR cohort to represent a wide range of iAs exposure as determined by iAs in drinking water (DW-iAs). The exposure during pregnancy was confirmed using U-tAs. A total of 50 cord blood serum samples were used in the metabolomics analysis The samples included 25 newborns with lower maternal iAs exposure levels (DW < 25?g As/L, mean U-tAs=16 ?g/L) and 25 newborns with higher maternal iAs exposure levels (DW> 25?g As/L, mean U-tAs =107 ?g/L).
University of North Carolina
DepartmentSystems and Translational Sciences
LaboratorySumner Lab
Last NameSumner
First NameSusan
AddressEastern Regional Comprehensive Metabolomics Resource Core, UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC, 28081
Submit Date2014-04-30
Num Groups2
Total Subjects50
Raw Data AvailableYes
Raw Data File Type(s)uxnmr.par, .txt, binary files under dir pdata
Uploaded File Size31 M
Analysis Type DetailNMR
Release Date2018-08-27
Release Version1
Susan Sumner Susan Sumner application/zip

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Project ID:PR000049
Project DOI:doi: 10.21228/M8W88R
Project Title:Biomarkers of Exposure to ARsenic (BEAR) study
Project Type:Environmental exposure
Project Summary:The BEAR study has been established to assess the health effects associated with prenatal arsenic exposure during neonatal and early life. The study area is in Gómez Palacio, Durango, Mexico where women are exposed to levels of iAs in drinking water up to 236.0 ?g As/L.
Institute:University of North Carolina at Chapel Hill
Department:School of Public Health
Laboratory:Rebecca Fry Laboratory
Last Name:Fry
First Name:Rebecca
Address:1213 Michael Hooker Research Center, 135 Dauer Drive, Campus Box 7431, Chapel Hill, NC 27599
Funding Source:NIEHS