Summary of study ST000253

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000205. The data can be accessed directly via it's Project DOI: 10.21228/M8WK5Q This work is supported by NIH grant, U2C- DK119886.


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Study IDST000253
Study TitleNIH WCMC Pilot & Feasibility Project: “Metabolomics of Neonatal Pulmonary Hypertension”
Study TypeTreatment and feeding study
Study SummaryTargeted metabolomic analyses of oxylipins were performed on 16 rat plasma and lung samples collected from rats euthanized at 14 days following exposure to growth restriction and/or hyperoxia. Samples were analyzed by UPLC-MS/MS using a Waters Acquity UPLC and detected on an API 4000 QTrap (AB Sciex, Framingham, MA, USA) by multiple reaction monitoring (MRM) after negative mode electrospray ionization.
University of California, Davis
DepartmentU.S.D.A. Western Human Nutrition Research Center
LaboratoryNewman Lab
Last NameNewman
First NameJohn
Address430 W. Health Sciences Dr., Davis, CA 95616
Submit Date2015-09-03
Num Groups4
Total Subjects16
Raw Data AvailableYes
Raw Data File Type(s).mzML
Uploaded File Size16 M
Analysis Type DetailLC-MS
Release Date2015-09-14
Release Version1
John Newman John Newman application/zip

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Project ID:PR000205
Project DOI:doi: 10.21228/M8WK5Q
Project Title:Metabolomics of Neonatal Pulmonary Hypertension (in a Rat Model)
Project Type:Treatment and feeding study
Project Summary:This study aims to identify identify disrupted metabolic pathways and patterns of lung developent in a rat model of bronchopulmonary dysplasia and growth restriction. Pregnant Sprague Dawley rats (gestational day 15) were housed in plsatic cages under constant conditions. After 7-d acclimization period, litters were delivered and pups randomly distributed between litters of 10 pups (N, normal intake) or litters of 17 pups (R, restricted intake). Normal and restriced intake pups were exposed to 75% oxygen (O, oxygen) in a Plexiglass chamber or to 21% oxygen (A, room air) continuously for 14 days, with daily rotation of dams to avoid oxygen toxicity. Both plasma and lung tissue underwent metabolomics analysis.
Institute:University of California, Davis
Department:Department of Pediatrics, School of Medicine
Laboratory:Wedgwood lab
Last Name:Wedgwood
First Name:Stephen
Address:1002B, Research II, 4625 2nd Ave., Sacramento, CA 95817
Funding Source:National Institute of Health U24 DK092993