Summary of Study ST000552

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000404. The data can be accessed directly via it's Project DOI: 10.21228/M8TS4S This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000552
Study TitleMetabolite signatures in trauma patients with venous thromboembolism (VTE)
Study TypeClinical
Study Summaryretrospective study of metabolite signatures in trauma patients with venous thromboembolism (VTE).
Institute
University of Florida
DepartmentSECIM
Last NameVoils
First NameStacy
AddressUF College of Pharmacy
Emailsvoils@cop.ufl.edu
Phone352-294-5276
Submit Date2017-02-03
Num Groups2
Total Subjects40
Raw Data AvailableYes
Raw Data File Type(s)mzML
Analysis Type DetailLC-MS
Release Date2018-02-07
Release Version1
Stacy Voils Stacy Voils
https://dx.doi.org/10.21228/M8TS4S
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR000404
Project DOI:doi: 10.21228/M8TS4S
Project Title:Metabolite signatures in trauma patients with venous thromboembolism
Project Summary:Metabolyte signatures in trauma patients with venous thromboembolism
Institute:University of Florida
Department:College of Pharmacy - Pharmacotherapy and Translational Research
Last Name:Voils
First Name:Stacy
Address:UF College of Pharmacy
Email:svoils@cop.ufl.edu
Phone:352-294-5276
Funding Source:Departmental

Subject:

Subject ID:SU000574
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Gender:Male
Human Race:White
Human Inclusion Criteria:blunt trauma without isolated head injury, defined as either abbreviated injury score (AIS) head <4 OR Glasgow Coma Scale (GCS) motor >3 within 24 hours of injury, emergency department arrival within 6 hours from time of injury, blood transfusion within 12 hours of injury, base deficit of at least 6 or systolic blood pressure <90 mmHg within 60 minutes of emergency department arrival, and fully or partially intact cervical spinal cord
Human Exclusion Criteria:age <16 years, anticipated survival of <24 hours from injury, anticipated survival <28 days due to pre-existing medical condition, inability to obtain first blood draw within first 12 hours after injury, traumatic brain injury (i.e., GCS ≤8 after ICU admission AND brain computerized tomography scan abnormality within 12 hours after injury), immunosuppression, significant pre-existing organ dysfunction, and receiving home oxygen therapy
Species Group:Mammals

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id VTE
SA028681234653no
SA028682136727no
SA028683134517no
SA028684115398no
SA028685229230no
SA028686144326no
SA028687312111no
SA028688117547no
SA028689264516no
SA028690254695no
SA028691277941no
SA028692173497no
SA028693254703no
SA028694160528no
SA028695254698no
SA028696232040no
SA028697234629no
SA028698277961no
SA028699257257no
SA028700384019no
SA028701234641yes
SA028702271608yes
SA028703375180yes
SA028704173583yes
SA028705242646yes
SA028706121976yes
SA028707365185yes
SA028708257264yes
SA028709171295yes
SA028710120370yes
SA028711162601yes
SA028712166755yes
SA028713313142yes
SA028714164415yes
SA028715319847yes
SA028716319819yes
SA028717258084yes
SA028718150226yes
SA028719232036yes
SA028720310342yes
Showing results 1 to 40 of 40

Collection:

Collection ID:CO000568
Collection Summary:Whole blood samples were collected within 24 hours of hospital admission into EDTA-containing vacutainers (purple top). Samples were centrifuged at 2,500 g for 10 minutes to generate plasma which was then frozen continuously at -80 C.
Sample Type:Blood

Treatment:

Treatment ID:TR000588
Treatment Summary:none
Human Fasting:likely fasting

Sample Preparation:

Sampleprep ID:SP000581
Sampleprep Summary:None
Sampleprep Protocol Filename:Metabolomics_Global_LCMS.pdf
Metabolomics_LCMSProtocol_plasma.pdf

Combined analysis:

Analysis ID AN000843 AN000844
Analysis type MS MS
Chromatography type Reversed phase Reversed phase
Chromatography system Thermo Scientific Q-Exactive Thermo Scientific Q-Exactive
Column ACE Excel 2 C18-PFP (100 x 2.1mm, 2um) ACE Excel 2 C18-PFP (100 x 2.1mm, 2um)
MS Type ESI ESI
MS instrument type Orbitrap Orbitrap
MS instrument name Thermo Q Exactive Orbitrap Thermo Q Exactive Orbitrap
Ion Mode POSITIVE NEGATIVE
Units Peak height Peak height

Chromatography:

Chromatography ID:CH000603
Methods Filename:Metabolomics_LCMSProtocol_plasma.pdf
Instrument Name:Thermo Scientific Q-Exactive
Column Name:ACE Excel 2 C18-PFP (100 x 2.1mm, 2um)
Flow Rate:0.350mL/min-0.600mL/min
Solvent A:100% water; 0.1% formic acid
Solvent B:100% acetonitrile
Chromatography Type:Reversed phase

MS:

MS ID:MS000744
Analysis ID:AN000843
Instrument Name:Thermo Q Exactive Orbitrap
Instrument Type:Orbitrap
MS Type:ESI
Ion Mode:POSITIVE
Analysis Protocol File:Metabolomics_LCMSProtocol_plasma.pdf
  
MS ID:MS000745
Analysis ID:AN000844
Instrument Name:Thermo Q Exactive Orbitrap
Instrument Type:Orbitrap
MS Type:ESI
Ion Mode:NEGATIVE
Analysis Protocol File:Metabolomics_LCMSProtocol_plasma.pdf
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