Summary of Study ST000705

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000502. The data can be accessed directly via it's Project DOI: 10.21228/M8S37Q This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000705
Study TitleSlow Aging Mice Plasma Metabolomics
Study TypeMS analysis
Study SummaryPlasma from young adult mice, fasted 4 hr prior to bleeding. Key comparisons: Snell dwarf vs Snell normal. GHRKO KO vs WT. PAPPA KO vs Het. And two factor ANOVA: LivGHR KO, LivGHR WT vs GHRKO and GHRWT. Consistency between Snell, GHRKO, and PAPPA will be a major theme in the analysis.
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Emailmkachman@med.umich.edu
Phone(734) 232-8175
Submit Date2017-06-19
Num Groups14
Total Subjects17
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2017-12-06
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8S37Q
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR000502
Project DOI:doi: 10.21228/M8S37Q
Project Title:Slow Aging Mice Studies
Project Type:MS analysis
Project Summary:Plasma from slow-aging mice
Institute:University of Michigan
Department:Pathology
Laboratory:Miller Lab
Last Name:Miller
First Name:Richard
Address:University Michigan, 2900 Huron Parkway, Ann Arbor, MI 48105
Email:millerr@umich.edu
Phone:734-936-2122

Subject:

Subject ID:SU000728
Subject Type:Mouse
Subject Species:Mus musculus
Taxonomy ID:10090
Species Group:Mammals

Factors:

Subject type: Mouse; Subject species: Mus musculus (Factor headings shown in green)

mb_sample_id local_sample_id Genotype Sex Strain
SA039779S00019810Dwarf F Snell
SA039780S00019806Dwarf F Snell
SA039781S00019804Dwarf F Snell
SA039782S00019818Dwarf F Snell
SA039783S00019816Dwarf F Snell
SA039784S00019800Dwarf F Snell
SA039785S00019802Dwarf F Snell
SA039786S00019808Dwarf F Snell
SA039787S00019822Dwarf M Snell
SA039788S00019824Dwarf M Snell
SA039789S00019814Dwarf M Snell
SA039790S00019820Dwarf M Snell
SA039791S00019812Dwarf M Snell
SA039792S00019826Dwarf M Snell
SA039793S00019895Het F PappA
SA039794S00019909Het F PappA
SA039795S00019896Het F PappA
SA039796S00019905Het F PappA
SA039797S00019885Het F PappA
SA039798S00019884Het F PappA
SA039799S00019907Het F PappA
SA039800S00019903Het F PappA
SA039801S00019893Het M PappA
SA039802S00019891Het M PappA
SA039803S00019888Het M PappA
SA039804S00019889Het M PappA
SA039805S00019901Het M PappA
SA039806S00019899Het M PappA
SA039807S00019846KO F GHRKO Global
SA039808S00019836KO F GHRKO Global
SA039809S00019838KO F GHRKO Global
SA039810S00019850KO F GHRKO Global
SA039811S00019852KO F GHRKO Global
SA039812S00019829KO F GHRKO Global
SA039813S00019844KO F GHRKO Global
SA039814S00019830KO F GHRKO Global
SA039815S00019906KO F PappA
SA039816S00019908KO F PappA
SA039817S00019910KO F PappA
SA039818S00019887KO F PappA
SA039819S00019886KO F PappA
SA039820S00019904KO F PappA
SA039821S00019897KO F PappA
SA039822S00019898KO F PappA
SA039823S00019847KO M GHRKO Global
SA039824S00019832KO M GHRKO Global
SA039825S00019839KO M GHRKO Global
SA039826S00019828KO M GHRKO Global
SA039827S00019840KO M GHRKO Global
SA039828S00019843KO M GHRKO Global
SA039829S00019900KO M PappA
SA039830S00019902KO M PappA
SA039831S00019890KO M PappA
SA039832S00019883KO M PappA
SA039833S00019894KO M PappA
SA039834S00019892KO M PappA
SA039835S00019871Neg F Liver GHRKO
SA039836S00019870Neg F Liver GHRKO
SA039837S00019869Neg F Liver GHRKO
SA039838S00019878Neg F Liver GHRKO
SA039839S00019860Neg F Liver GHRKO
SA039840S00019880Neg F Liver GHRKO
SA039841S00019882Neg F Liver GHRKO
SA039842S00019859Neg F Liver GHRKO
SA039843S00019874Neg M Liver GHRKO
SA039844S00019875Neg M Liver GHRKO
SA039845S00019867Neg M Liver GHRKO
SA039846S00019855Neg M Liver GHRKO
SA039847S00019866Neg M Liver GHRKO
SA039848S00019856Neg M Liver GHRKO
SA039849S00019805Normal F Snell
SA039850S00019803Normal F Snell
SA039851S00019807Normal F Snell
SA039852S00019809Normal F Snell
SA039853S00019817Normal F Snell
SA039854S00019815Normal F Snell
SA039855S00019801Normal F Snell
SA039856S00019799Normal F Snell
SA039857S00019813Normal M Snell
SA039858S00019811Normal M Snell
SA039859S00019825Normal M Snell
SA039860S00019819Normal M Snell
SA039861S00019823Normal M Snell
SA039862S00019821Normal M Snell
SA039863S00020157Pooled plasma Pooled plasma Pooled plasma
SA039864S00019868Pos F Liver GHRKO
SA039865S00019872Pos F Liver GHRKO
SA039866S00019863Pos F Liver GHRKO
SA039867S00019862Pos F Liver GHRKO
SA039868S00019877Pos F Liver GHRKO
SA039869S00019881Pos F Liver GHRKO
SA039870S00019879Pos F Liver GHRKO
SA039871S00019861Pos F Liver GHRKO
SA039872S00019858Pos M Liver GHRKO
SA039873S00019864Pos M Liver GHRKO
SA039874S00019865Pos M Liver GHRKO
SA039875S00019876Pos M Liver GHRKO
SA039876S00019873Pos M Liver GHRKO
SA039877S00019857Pos M Liver GHRKO
SA039878S00019845WT F GHRKO Global
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Collection:

Collection ID:CO000722
Collection Summary:-
Sample Type:Blood

Treatment:

Treatment ID:TR000742
Treatment Summary:-

Sample Preparation:

Sampleprep ID:SP000735
Sampleprep Summary:-
Sampleprep Protocol Filename:A003_-_Untargeted_Metabolomics.pdf

Combined analysis:

Analysis ID AN001095 AN001096
Analysis type MS MS
Chromatography type Reversed phase Reversed phase
Chromatography system Agilent Agilent
Column Waters Acquity HSS T3 (50 x 2.1mm,1.8um) Waters Acquity HSS T3 (50 x 2.1mm,1.8um)
MS Type ESI ESI
MS instrument type QTOF QTOF
MS instrument name Agilent 6530 QTOF Agilent 6530 QTOF
Ion Mode POSITIVE NEGATIVE
Units peak area normalized peak area normalized

Chromatography:

Chromatography ID:CH000770
Instrument Name:Agilent
Column Name:Waters Acquity HSS T3 (50 x 2.1mm,1.8um)
Chromatography Type:Reversed phase

MS:

MS ID:MS000990
Analysis ID:AN001095
Instrument Name:Agilent 6530 QTOF
Instrument Type:QTOF
MS Type:ESI
Ion Mode:POSITIVE
Analysis Protocol File:A003_-_Untargeted_Metabolomics.pdf
  
MS ID:MS000991
Analysis ID:AN001096
Instrument Name:Agilent 6530 QTOF
Instrument Type:QTOF
MS Type:ESI
Ion Mode:NEGATIVE
Analysis Protocol File:A003_-_Untargeted_Metabolomics.pdf
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