Summary of Study ST000721

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000518. The data can be accessed directly via it's Project DOI: 10.21228/M8Q68H This work is supported by NIH grant, U2C- DK119886.

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Study IDST000721
Study TitleMetabolomic Profiles of Recovery from Traumatic Brain Injury
Study TypeMS analysis
Study SummaryWe hypothesize that differences between the metabolome of TBI patients achieving full recovery at 3 months post-injury and those with protracted recovery will provide insights into the biology of recovery and yield novel biomarkers for predicting protracted recovery. To test our hypothesis, we will perform a case-control study examining the metabolomic profile of 128 TBI patients, 18 years and older, who either have complete functional recovery at 3 months post-injury or have functional decline at 3 months post-injury. Subjects were selected from an ongoing prospective cohort of traumatic brain injury (Head Injury Serum Markers for Assessing Response to Trauma, HeadSMART. Funding for HeadSMART was provided by ImmunArray.
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Emailmkachman@med.umich.edu
Submit Date2017-06-19
Num Groups71
Total Subjects128
Raw Data AvailableYes
Raw Data File Type(s)bin
Analysis Type DetailLC-MS
Release Date2017-12-06
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8Q68H
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR000518
Project DOI:doi: 10.21228/M8Q68H
Project Title:Metabolomic Profiles of Recovery from Traumatic Brain Injury
Project Type:MS analysis
Project Summary:Exploring the metabolome of TBI patients on the day of injury and at 3 months after injury
Institute:University of Michigan
Department:Emergency Medicine
Laboratory:Korley Lab
Last Name:Korley
First Name:Frederick
Address:Ann Arbor, MI
Email:korley@med.umich.edu

Subject:

Subject ID:SU000744
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Species Group:Mammals

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id CT findings GOSE Gender Injury
SA040394S00025656Abnormal only 4 Male 1 month
SA040395S00025648Abnormal only 4 Male 1 month
SA040396S00025776Abnormal only 4 Male 3 months
SA040397S00025742Abnormal only 5 Female 1 month
SA040398S00025731Abnormal only 5 Male 1 month
SA040399S00025859Abnormal only 5 Male 3 months
SA040400S00025719Abnormal only 6 Female 1 month
SA040401S00025847Abnormal only 6 Female 3 months
SA040402S00025870Abnormal only 6 Female 3 months
SA040403S00025717Abnormal only 6 Male 1 month
SA040404S00025704Abnormal only 6 Male 1 month
SA040405S00025663Abnormal only 6 Male 1 month
SA040406S00025658Abnormal only 6 Male 1 month
SA040407S00025784Abnormal only 6 Male 3 months
SA040408S00025845Abnormal only 6 Male 3 months
SA040409S00025689Abnormal only 7 Female 1 month
SA040410S00025817Abnormal only 7 Female 3 months
SA040411S00025659Abnormal only 7 Male 1 month
SA040412S00025696Abnormal only 7 Male 1 month
SA040413S00025703Abnormal only 7 Male 1 month
SA040414S00025747Abnormal only 7 Male 1 month
SA040415S00025679Abnormal only 7 Male 1 month
SA040416S00025755Abnormal only 7 Male 1 month
SA040417S00025734Abnormal only 7 Male 1 month
SA040418S00025824Abnormal only 7 Male 3 months
SA040419S00025807Abnormal only 7 Male 3 months
SA040420S00025786Abnormal only 7 Male 3 months
SA040421S00025787Abnormal only 7 Male 3 months
SA040422S00025832Abnormal only 7 Male 3 months
SA040423S00025883Abnormal only 7 Male 3 months
SA040424S00025890Abnormal only 7 Male 3 months
SA040425S00025831Abnormal only 7 Male 3 months
SA040426S00025706Abnormal only 8 Male 1 month
SA040427S00025762Abnormal only 8 Male 1 month
SA040428S00025642Abnormal only 8 Male 1 month
SA040429S00025862Abnormal only 8 Male 3 months
SA040430S00025770Abnormal only 8 Male 3 months
SA040431S00025875Abnormal only 8 Male 3 months
SA040432S00025791Abnormal only 8 Male 3 months
SA040433S00025834Abnormal only 8 Male 3 months
SA040434S00025798Normal 4 Male 3 months
SA040435S00025687Normal 5 Female 1 month
SA040436S00025686Normal 5 Female 1 month
SA040437S00025752Normal 5 Female 1 month
SA040438S00025735Normal 5 Female 1 month
SA040439S00025709Normal 5 Female 1 month
SA040440S00025644Normal 5 Female 1 month
SA040441S00025707Normal 5 Female 1 month
SA040442S00025671Normal 5 Female 1 month
SA040443S00025829Normal 5 Female 3 months
SA040444S00025814Normal 5 Female 3 months
SA040445S00025877Normal 5 Female 3 months
SA040446S00025815Normal 5 Female 3 months
SA040447S00025772Normal 5 Female 3 months
SA040448S00025754Normal 5 Male 1 month
SA040449S00025715Normal 5 Male 1 month
SA040450S00025684Normal 5 Male 1 month
SA040451S00025652Normal 5 Male 1 month
SA040452S00025737Normal 5 Male 1 month
SA040453S00025739Normal 5 Male 1 month
SA040454S00025780Normal 5 Male 3 months
SA040455S00025812Normal 5 Male 3 months
SA040456S00025882Normal 5 Male 3 months
SA040457S00025854Normal 5 Male 3 months
SA040458S00025843Normal 5 Male 3 months
SA040459S00025749Normal 6 Female 1 month
SA040460S00025730Normal 6 Female 1 month
SA040461S00025748Normal 6 Female 1 month
SA040462S00025661Normal 6 Female 1 month
SA040463S00025676Normal 6 Female 1 month
SA040464S00025643Normal 6 Female 1 month
SA040465S00025701Normal 6 Female 1 month
SA040466S00025740Normal 6 Female 1 month
SA040467S00025736Normal 6 Female 1 month
SA040468S00025880Normal 6 Female 3 months
SA040469S00025876Normal 6 Female 3 months
SA040470S00025863Normal 6 Female 3 months
SA040471S00025835Normal 6 Female 3 months
SA040472S00025844Normal 6 Female 3 months
SA040473S00025799Normal 6 Female 3 months
SA040474S00025864Normal 6 Female 3 months
SA040475S00025733Normal 6 Male 1 month
SA040476S00025745Normal 6 Male 1 month
SA040477S00025738Normal 6 Male 1 month
SA040478S00025741Normal 6 Male 1 month
SA040479S00025744Normal 6 Male 1 month
SA040480S00025732Normal 6 Male 1 month
SA040481S00025693Normal 6 Male 1 month
SA040482S00025688Normal 6 Male 1 month
SA040483S00025764Normal 6 Male 1 month
SA040484S00025667Normal 6 Male 1 month
SA040485S00025682Normal 6 Male 1 month
SA040486S00025681Normal 6 Male 1 month
SA040487S00025649Normal 6 Male 1 month
SA040488S00025651Normal 6 Male 1 month
SA040489S00025713Normal 6 Male 1 month
SA040490S00025647Normal 6 Male 1 month
SA040491S00025720Normal 6 Male 1 month
SA040492S00025889Normal 6 Male 3 months
SA040493S00025885Normal 6 Male 3 months
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Collection:

Collection ID:CO000738
Collection Summary:-
Sample Type:Blood

Treatment:

Treatment ID:TR000758
Treatment Summary:-

Sample Preparation:

Sampleprep ID:SP000751
Sampleprep Summary:-
Sampleprep Protocol Filename:A003_-_Untargeted_Metabolomics.pdf

Combined analysis:

Analysis ID AN001127 AN001128
Analysis type MS MS
Chromatography type Reversed phase Reversed phase
Chromatography system Agilent Agilent
Column Waters Acquity HSS T3 (50 x 2.1mm,1.8um) Waters Acquity HSS T3 (50 x 2.1mm,1.8um)
MS Type ESI ESI
MS instrument type QTOF QTOF
MS instrument name Agilent 6530 QTOF Agilent 6530 QTOF
Ion Mode POSITIVE NEGATIVE
Units peak area normalized peak area normalized

Chromatography:

Chromatography ID:CH000793
Instrument Name:Agilent
Column Name:Waters Acquity HSS T3 (50 x 2.1mm,1.8um)
Chromatography Type:Reversed phase

MS:

MS ID:MS001022
Analysis ID:AN001127
Instrument Name:Agilent 6530 QTOF
Instrument Type:QTOF
MS Type:ESI
Ion Mode:POSITIVE
Analysis Protocol File:A003_-_Untargeted_Metabolomics.pdf
  
MS ID:MS001023
Analysis ID:AN001128
Instrument Name:Agilent 6530 QTOF
Instrument Type:QTOF
MS Type:ESI
Ion Mode:NEGATIVE
Analysis Protocol File:A003_-_Untargeted_Metabolomics.pdf
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