Summary of study ST000724

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000521. The data can be accessed directly via it's Project DOI: 10.21228/M89X00 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000724
Study TitleRed squirrels age related changes
Study TypeMS analysis
Study SummaryMetabolomics has recently been used to document age-related changes in key metabolic pathways in laboratory animals and as a biomarker to predict age. We study the ecology, evolution, behavior, and physiology of wild North American red squirrels where we are able to follow individual squirrels across their lifetime from birth until death. We are beginning to document aging in this natural population and are interested in understanding whether there is a signature of aging using metabolomics. We collected plasma samples from the oldest female and male squirrels in our study population and also from an equivalent number of younger squirrels. We will use an untargeted approach to provide an assessment of what metabolites differ among very old and young squirrels. The aim of these analyses is to allow us to identify if the same metabolites that have been identified as biomarkers of advanced age from laboratory mice are also biomarkers of advanced age in red squirrels. After we complete these untargeted analyses, we aim to develop a metabolomics panel for this species so that we can use a more targeted approach to assess how the metabolic profiles of specific pathways (glucose/fatty acid metabolism, redox homeostasis) change with age in offspring exposed to increased perinatal stress in our study species.
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Emailmkachman@med.umich.edu
Phone(734) 232-8175
Submit Date2017-06-19
Num Groups6
Total Subjects33
Study CommentsMetabolomics has recently been used to document age-related changes in key metabolic pathways in laboratory animals and as a biomarker to predict age. We study the ecology, evolution, behavior, and physiology of wild North American red squirrels where we are able to follow individual squirrels across their lifetime from birth until death. We are beginning to document aging in this natural population and are interested in understanding whether there is a signature of aging using metabolomics.
Raw Data AvailableYes
Raw Data File Type(s).d
Analysis Type DetailLC-MS
Release Date2017-12-06
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M89X00
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR000521
Project DOI:doi: 10.21228/M89X00
Project Title:Age related changes in metabolomics in red squirrels
Project Type:MS analysis
Project Summary:Pilot analyses for age-related changes in physiology in wild North American red squirrels
Institute:University of Michigan
Department:Psychology
Laboratory:Dantzer Lab
Last Name:Dantzer
First Name:Ben
Address:Ann Arbor, MI
Email:dantzer@umich.edu
Phone:734-615-2352
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