Summary of Study ST000763

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000551. The data can be accessed directly via it's Project DOI: 10.21228/M8FH50 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000763
Study TitleUntargeted metabolomics and lipidomics of scleroderma PAH discovery cohort
Study TypeMS analysis
Study SummaryThis experiment was performed using the following cohorts: 1) healthy controls, 2) patients with scleroderma at low risk for pulmonary hypertension, 3) pateints with scleroderma at high risk for pulmonary hypertension who underwent a catheterization and were found to have normal pressures, borderline elevated pressures or pulmonary arterial hypertensino (PAH). Whole blood was drawn directly into EDTA tubes at rest and again at peak exercise for each human subject. The samples were processed to plasma by MCRU and stored at -80 in the Biorepository.
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Emailmkachman@med.umich.edu
Phone(734) 232-8175
Submit Date2017-06-19
Num Groups11
Total Subjects5
Raw Data AvailableYes
Raw Data File Type(s)wiff
Analysis Type DetailLC-MS
Release Date2017-12-06
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M8FH50
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR000551
Project DOI:doi: 10.21228/M8FH50
Project Title:Untargeted and lipidomics_scleroderma_PAH
Project Type:MS analysis
Project Summary:Untargeted/lipidomics analysis
Institute:University of Michigan
Department:Internal Medicine-Cardiology
Laboratory:Visovatti Lab
Last Name:Visovatti
First Name:Scott
Address:Ann Arbor, MI
Email:shv@med.umich.edu
Phone:734-657-6917

Subject:

Subject ID:SU000786
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Species Group:Mammals

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Exercise Group Sex Type
SA041771S00021447No Borderline Pressures Female Cath
SA041772S00021449No Borderline Pressures Female Cath
SA041773S00021453No Borderline Pressures Female Cath
SA041774S00021358No Borderline Pressures Female Cath
SA041775S00021271No Borderline Pressures Female Cath
SA041776S00021368No Borderline Pressures Female Cath
SA041777S00021364No Borderline Pressures Female Cath
SA041778S00021285No Borderline Pressures Female Cath
SA041779S00021279No Borderline Pressures Female Cath
SA041780S00021257No Borderline Pressures Female Cath
SA041781S00021269No Borderline Pressures Female Cath
SA041782S00021349No Borderline Pressures Female Cath
SA041783S00021378No Borderline Pressures Female Cath
SA041784S00021345No Borderline Pressures Female Cath
SA041785S00021265No Borderline Pressures Female Cath
SA041786S00021267No Borderline Pressures Female Cath
SA041787S00021291No Borderline Pressures Female Cath
SA041788S00021411No Borderline Pressures Female Cath
SA041789S00021301No Borderline Pressures Male Cath
SA041790S00021374No Borderline Pressures Male Cath
SA041791S00021305No Borderline Pressures Male Cath
SA041792S00021389No Healthy Female Non-invasive
SA041793S00021311No Healthy Female Non-invasive
SA041794S00021387No Healthy Female Non-invasive
SA041795S00021309No Healthy Female Non-invasive
SA041796S00021356No Healthy Female Non-invasive
SA041797S00021339No Healthy Female Non-invasive
SA041798S00021327No Healthy Female Non-invasive
SA041799S00021329No Healthy Female Non-invasive
SA041800S00021337No Healthy Female Non-invasive
SA041801S00021331No Healthy Female Non-invasive
SA041802S00021325No Healthy Female Non-invasive
SA041803S00021323No Healthy Female Non-invasive
SA041804S00021362No Healthy Female Non-invasive
SA041805S00021315No Healthy Female Non-invasive
SA041806S00021317No Healthy Female Non-invasive
SA041807S00021391No Healthy Female Non-invasive
SA041808S00021321No Healthy Female Non-invasive
SA041809S00021313No Healthy Female Non-invasive
SA041810S00021401No Healthy Female Non-invasive
SA041811S00021427No Healthy Female Non-invasive
SA041812S00021425No Healthy Female Non-invasive
SA041813S00021423No Healthy Female Non-invasive
SA041814S00021429No Healthy Female Non-invasive
SA041815S00021437No Healthy Female Non-invasive
SA041816S00021469No Healthy Female Non-invasive
SA041817S00021273No Healthy Female Non-invasive
SA041818S00021275No Healthy Female Non-invasive
SA041819S00021415No Healthy Female Non-invasive
SA041820S00021435No Healthy Female Non-invasive
SA041821S00021403No Healthy Female Non-invasive
SA041822S00021399No Healthy Female Non-invasive
SA041823S00021397No Healthy Female Non-invasive
SA041824S00021333No Healthy Female Non-invasive
SA041825S00021319No Healthy Male Non-invasive
SA041826S00021354No Healthy Male Non-invasive
SA041827S00021335No Healthy Male Non-invasive
SA041828S00021277No Healthy Male Non-invasive
SA041829S00021457No LowRisk Female Non-invasive
SA041830S00021461No LowRisk Female Non-invasive
SA041831S00021395No LowRisk Female Non-invasive
SA041832S00021471No LowRisk Female Non-invasive
SA041833S00021467No LowRisk Female Non-invasive
SA041834S00021465No LowRisk Female Non-invasive
SA041835S00021455No LowRisk Female Non-invasive
SA041836S00021459No LowRisk Female Non-invasive
SA041837S00021445No LowRisk Female Non-invasive
SA041838S00021382No LowRisk Female Non-invasive
SA041839S00021413No LowRisk Female Non-invasive
SA041840S00021376No LowRisk Female Non-invasive
SA041841S00021431No LowRisk Female Non-invasive
SA041842S00021433No LowRisk Female Non-invasive
SA041843S00021441No LowRisk Female Non-invasive
SA041844S00021393No LowRisk Female Non-invasive
SA041845S00021372No LowRisk Female Non-invasive
SA041846S00021366No LowRisk Female Non-invasive
SA041847S00021293No LowRisk Female Non-invasive
SA041848S00021287No LowRisk Female Non-invasive
SA041849S00021473No LowRisk Male Non-invasive
SA041850S00021405No LowRisk Male Non-invasive
SA041851S00021303No Normal Pressures Female Cath
SA041852S00021299No Normal Pressures Female Cath
SA041853S00021351No Normal Pressures Female Cath
SA041854S00021409No Normal Pressures Female Cath
SA041855S00021380No Normal Pressures Female Cath
SA041856S00021370No Normal Pressures Female Cath
SA041857S00021261No Normal Pressures Female Cath
SA041858S00021421No Normal Pressures Female Cath
SA041859S00021263No Normal Pressures Female Cath
SA041860S00021289No Normal Pressures Male Cath
SA041861S00021307No PAH Female Cath
SA041862S00021295No PAH Female Cath
SA041863S00021283No PAH Female Cath
SA041864S00021439No PAH Female Cath
SA041865S00021407No PAH Female Cath
SA041866S00021297No PAH Female Cath
SA041867S00021419No PAH Female Cath
SA041868S00021386No PAH Female Cath
SA041869S00021443No PAH Female Cath
SA041870S00021384No PAH Female Cath
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Collection:

Collection ID:CO000780
Collection Summary:-
Sample Type:Blood

Treatment:

Treatment ID:TR000800
Treatment Summary:-

Sample Preparation:

Sampleprep ID:SP000793
Sampleprep Summary:-
Sampleprep Protocol Filename:A003_-_Untargeted_Metabolomics.pdf

Chromatography:

Chromatography ID:CH000842
Instrument Name:Agilent
Column Name:Waters Acquity HSS T3 (50 x 2.1mm,1.8um)
Chromatography Type:Reversed phase
  
Chromatography ID:CH000843
Instrument Name:Shimadzu CTO-20A Nexera X2
Column Name:Waters Acquity HSS T3 (50 x 2.1mm,1.8um)
Column Temperature:55
Flow Rate:0.400uL/min
Solvent A:40% acetonitrile/60% water; 10 mM ammonium acetate
Solvent B:10% acetonitrile/5% water/85% isopropanol; 10 mM ammonium acetate
Chromatography Type:Reversed phase

Analysis:

Analysis ID:AN001201
Analysis Type:MS
Analysis Protocol File:A003_-_Untargeted_Metabolomics.pdf
Instrument Name:6530 Q-TOF LC/MS (Agilent)
Chromatography ID:CH000842
Num Factors:20
Num Metabolites:138
Has Mz:1
Has Rt:1
Rt Units:Minutes
Units:peak area normalized
  
Analysis ID:AN001202
Analysis Type:MS
Analysis Protocol File:A003_-_Untargeted_Metabolomics.pdf
Instrument Name:6530 Q-TOF LC/MS (Agilent)
Chromatography ID:CH000842
Num Factors:20
Num Metabolites:133
Has Mz:1
Has Rt:1
Rt Units:Minutes
Units:peak area normalized
  
Analysis ID:AN001203
Analysis Type:MS
Analysis Protocol File:A004_-_Shotgun_Lipidomics.pdf
Instrument Name:TripleTOF 5600+ (Absciex)
Chromatography ID:CH000843
Num Factors:20
Num Metabolites:126
Rt Units:Minutes
Units:peak area normalized
  
Analysis ID:AN001204
Analysis Type:MS
Analysis Protocol File:A004_-_Shotgun_Lipidomics.pdf
Instrument Name:TripleTOF 5600+ (Absciex)
Chromatography ID:CH000843
Num Factors:20
Num Metabolites:276
Rt Units:Minutes
Units:peak area normalized
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