Summary of study ST000834

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000595. The data can be accessed directly via it's Project DOI: 10.21228/M8RQ4G This work is supported by NIH grant, U2C- DK119886.


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Study IDST000834
Study TitlePurine and TCA measurements in salt sensitive (SS) hypertension
Study TypeMS analysis
Study SummarySS rats were surgically implanted with a chronic servo-control cuff, the purpose of which is to maintain normal pressure to the left kidney while the right kidney is exposed to high blood pressure. After 7 days of high salt treatment, which induces high blood pressure in the SS rat, rats were anesthetized with pentobarbital, kidneys were flushed and removed. The renal medulla was separated from the cortex using scissors, and the renal medullas were frozen in liquid nitrogen and stored at -80 C.
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Phone(734) 232-8175
Submit Date2017-08-02
Num Groups11
Total Subjects4
Raw Data AvailableYes
Raw Data File Type(s).d
Analysis Type DetailGC/LC-MS
Release Date2018-02-07
Release Version1
Maureen Kachman Maureen Kachman application/zip

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Project ID:PR000595
Project DOI:doi: 10.21228/M8RQ4G
Project Title:Purine and TCA Measurements in SS Hypertension
Project Type:MS analysis
Project Summary:Based on RNA-seq ontological and Bayesian analyses, both purine levels and TCA-cycle intermediates have been nominated as being regulated by pressure in the SS rat. This project seeks to verify the previous RNA-seq prediction.
Institute:Medical College of Wisconsin
Laboratory:Cowley Lab
Last Name:Cowley
First Name:Allen
Address:Milwaukee, WI