Summary of study ST000836

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench,, where it has been assigned Project ID PR000596. The data can be accessed directly via it's Project DOI: 10.21228/M8MX15 This work is supported by NIH grant, U2C- DK119886.


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Study IDST000836
Study TitlePilot Human Muscle oral glucose tolerance test (OGTT)
Study TypeMS analysis
Study SummaryObesity is associated with metabolic inflexibility, the inability to switch from lipid to glucose oxidation during physiological conditions favoring excess glucose and insulin, which could contribute to the increased incidence of type 2 diabetes. Despite this knowledge, the role of skeletal muscle metabolites during these physiological conditions remain unclear and warrant further investigation. The purpose of this pilot study is to determine if: 1) there are differences in skeletal muscle glycolysis and TCA metabolites and amino acids between lean and obese individuals in the fasted state, and 2) if these metabolites change after 50 min of glucose ingestion, and 3) if there are differences in these metabolites between lean and obese individuals after 50 min of glucose ingestion.
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
Address6300 Brehm Tower, 1000 Wall Street, Ann Arbor, MI 48105-5714
Phone(734) 232-8175
Submit Date2017-08-02
Num Groups5
Total Subjects6
Raw Data AvailableYes
Raw Data File Type(s).d
Analysis Type DetailLC-MS
Release Date2018-02-07
Release Version1
Maureen Kachman Maureen Kachman application/zip

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Project ID:PR000596
Project DOI:doi: 10.21228/M8MX15
Project Title:Lean Obese Human Glucose Metabolism
Project Type:MS analysis
Project Summary:Lean and obese skeletal muscle TCA plus response to OGTT
Institute:Ohio University
Department:Biomedical Sciences
Laboratory:Consitt Lab
Last Name:Consitt
First Name:Leslie
Address:Athens, Ohio