Summary of Study ST000919

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000635. The data can be accessed directly via it's Project DOI: 10.21228/M8KT1T This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000919
Study TitleInvestigating Eicosanoids Implications on the Blood Pressure Response to Thiazide Diuretics
Study TypeBlood pressure response to hydrochlorthiazide
Study SummaryIdentify eicosanoids significantly associated with the blood pressure response to hydrochlorothiazide
Institute
University of Florida
DepartmentPharmacotherapy and Translational Research
Last NameShahin
First NameMohamed
Address1600 SW Archer RD, Medical Science Building, Rm#PG-31
Emailmhossam@cop.ufl.edu
Phone352-273-6405
Submit Date2018-01-11
Num Groups2
Total Subjects140
Study Comments140 (70 subjects per group)
Raw Data AvailableYes
Raw Data File Type(s)mzXML
Analysis Type DetailLC-MS
Release Date2019-01-22
Release Version1
Mohamed Shahin Mohamed Shahin
https://dx.doi.org/10.21228/M8KT1T
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR000635
Project DOI:doi: 10.21228/M8KT1T
Project Title:Investigating Eicosanoids Implications on the Blood Pressure Response to Thiazide Diuretics
Project Type:Blood pressure response to hydrochlorthiazide
Project Summary:Identify eicosanoids significantly associated with the blood pressure response to hydrochlorothiazide
Institute:University of Florida
Department:Pharmacotherapy and Translational Research
Last Name:Shahin
First Name:Mohamed
Address:1600 SW Archer RD, Medical Science Building, Rm#PG-31
Email:mhossam@cop.ufl.edu
Phone:352-273-6405

Subject:

Subject ID:SU000957
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Species Group:Mammals

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Response Gender
SA054472PR0232NR Female
SA054473PR0654NR Female
SA054474PR0674NR Female
SA054475PR0060NR Female
SA054476PR0202NR Female
SA054477PR0119NR Female
SA054478PR0122NR Female
SA054479PF0456NR Female
SA054480PR0129NR Female
SA054481PF0427NR Female
SA054482PR0490NR Female
SA054483PF0120NR Female
SA054484PR0592NR Female
SA054485PF0226NR Female
SA054486PR0703NR Female
SA054487PF0001NR Female
SA054488PR0078NR Female
SA054489PE0109NR Female
SA054490PR0433NR Female
SA054491PR0443NR Female
SA054492PR0092NR Female
SA054493PE0248NR Female
SA054494PR0081NR Female
SA054495PR0700NR Female
SA054496PR0080NR Female
SA054497PR0369NR Female
SA054498PR0068NR Male
SA054499PF0576NR Male
SA054500PR0067NR Male
SA054501PF0574NR Male
SA054502PF0573NR Male
SA054503PF0533NR Male
SA054504PF0585NR Male
SA054505PR0187NR Male
SA054506PR0061NR Male
SA054507PR0051NR Male
SA054508PR0175NR Male
SA054509PR0566NR Male
SA054510PF0520NR Male
SA054511PR0206NR Male
SA054512PR0542NR Male
SA054513PF0597NR Male
SA054514PR0163NR Male
SA054515PR0457NR Male
SA054516PF0125NR Male
SA054517PR0339NR Male
SA054518PR0326NR Male
SA054519PF0227NR Male
SA054520PF0123NR Male
SA054521PR0686NR Male
SA054522PR0704NR Male
SA054523PE0160NR Male
SA054524PR0169NR Male
SA054525PF0043NR Male
SA054526PF0082NR Male
SA054527PR0319NR Male
SA054528PF0280NR Male
SA054529PR0184NR Male
SA054530PR0480NR Male
SA054531PF0454NR Male
SA054532PR0159NR Male
SA054533PF0490NR Male
SA054534PR0502NR Male
SA054535PR0585NR Male
SA054536PF0336NR Male
SA054537PF0292NR Male
SA054538PR0625NR Male
SA054539PR0313NR Male
SA054540PF0513NR Male
SA054541PR0599NR Male
SA054542PR0183R Female
SA054543PR0288R Female
SA054544PR0293R Female
SA054545PR0294R Female
SA054546PR0401R Female
SA054547PR0171R Female
SA054548PR0281R Female
SA054549PR0230R Female
SA054550PR0240R Female
SA054551PR0496R Female
SA054552PR0198R Female
SA054553PR0019R Female
SA054554PF0400R Female
SA054555PF0457R Female
SA054556PR0698R Female
SA054557PF0034R Female
SA054558PF0380R Female
SA054559PR0682R Female
SA054560PF0178R Female
SA054561PF0265R Female
SA054562PR0601R Female
SA054563PE0327R Female
SA054564PF0623R Female
SA054565PR0059R Female
SA054566PR0075R Female
SA054567PR0106R Female
SA054568PR0510R Female
SA054569PR0055R Female
SA054570PR0050R Female
SA054571PR0452R Female
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Collection:

Collection ID:CO000951
Collection Summary:Fasting plasma samples were collected at baseline (before hydrochlorothiazide)
Sample Type:Plasma

Treatment:

Treatment ID:TR000971
Treatment Summary:No treatment was given to any of the patients at the time of sample collection. Samples were collected before hydrochlorothiazide treatment.

Sample Preparation:

Sampleprep ID:SP000964
Sampleprep Summary:None (See files)
Sampleprep Protocol Filename:Appendix_A_-_Internal_Standard_Prep_GLCMS.pdf
GMetabolomics_LCMS_Protocol_092117.pdf

Combined analysis:

Analysis ID AN001506 AN001507
Analysis type MS MS
Chromatography type Reversed phase Reversed phase
Chromatography system Thermo Dionex Ultimate 3000 Thermo Dionex Ultimate 3000
Column ACE Excel 2 C18-PFP (100 x 2.1mm, 2um) ACE Excel 2 C18-PFP (100 x 2.1mm, 2um)
MS Type ESI ESI
MS instrument type Orbitrap Orbitrap
MS instrument name Thermo Q Exactive Orbitrap Thermo Q Exactive Orbitrap
Ion Mode POSITIVE NEGATIVE
Units Peak Height Peak Height

Chromatography:

Chromatography ID:CH001062
Methods Filename:GMetabolomics_LCMS_Protocol_092117.pdf
Instrument Name:Thermo Dionex Ultimate 3000
Column Name:ACE Excel 2 C18-PFP (100 x 2.1mm, 2um)
Flow Rate:350 ul/min
Solvent A:100% water; 0.1% formic acid
Solvent B:100% acetonitrile
Chromatography Type:Reversed phase

MS:

MS ID:MS001389
Analysis ID:AN001506
Instrument Name:Thermo Q Exactive Orbitrap
Instrument Type:Orbitrap
MS Type:ESI
Ion Mode:POSITIVE
  
MS ID:MS001390
Analysis ID:AN001507
Instrument Name:Thermo Q Exactive Orbitrap
Instrument Type:Orbitrap
MS Type:ESI
Ion Mode:NEGATIVE
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