Summary of study ST001054

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000707. The data can be accessed directly via it's Project DOI: 10.21228/M8911D This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001054
Study TitleFingerprinting gastrointestinal diseases by 1H NMR
Study SummaryWe studied 64 patients admitted to the Florence main hospital emergency room with severe abdominal pain. A blood sample was drawn from each patient at admission, and the corresponding sera underwent 1H NMR metabolomics fingerprinting. Unsupervised PCA analysis showed a significant discrimination between a group of patients with symptoms of upper abdominal pain and a second group consisting of patients with diffuse abdominal/intestinal pain. Prompted by this observation, supervised statistical analysis (OPLS-DA) showed a very good discrimination (> 90 %) between the two groups of symptoms. Actually in the present study, upper abdominal pain may result from either symptomatic gallstones, cholecystitis or pancreatitis, while diffuse abdominal/intestinal pain may result from either intestinal ischemia, strangulated obstruction or mechanical obstruction. Although limited by the small number of samples from each of these six conditions, discrimination of these diseases was attempted. In the first symptom group, > 70% discrimination accuracy was obtained among symptomatic gallstones, pancreatitis and cholecystitis, while for the second symptom group > 85% classification accuracy was obtained for intestinal ischemia, strangulated obstruction and mechanical obstruction. No single metabolite stands up as a possible biomarker for any of these diseases, while the contribution of the whole 1H NMR serum fingerprint seems to be a promising candidate, to be confirmed on larger cohorts, as a first-line discriminator for these diseases.
Institute
Giotto Biotech s.r.l.
Last NameTakis
First NamePanteleimon
AddressVia Madonna del Piano 6
Emailtakis@giottobiotech.com
Phone+393423233750
Submit Date2018-09-15
Raw Data AvailableYes
Raw Data File Type(s)pdata, .par, .temp, .fid,.scon2, ._audita.txt, ._auditp.txt, ._pulseprogram
Analysis Type DetailNMR
Release Date2018-09-27
Release Version1
Panteleimon Takis Panteleimon Takis
https://dx.doi.org/10.21228/M8911D
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR000707
Project DOI:doi: 10.21228/M8911D
Project Title:Fingerprinting gastrointestinal diseases by 1H NMR
Project Summary:A blood sample was drawn from each patient admitted to the Florence main hospital emergency room with severe abdominal pain. The corresponding sera underwent 1H NMR metabolomics fingerprinting to discriminate patients with symptoms of upper vs. diffuse abdominal/intestinal pain by the whole 1H NMR serum fingerprint and use it as a first-line discriminator for these symptoms and the diseases behind them.
Institute:Giotto Biotech s.r.l.
Last Name:Takis
First Name:Panteleimon
Address:Via Madonna del Piano 6, 50019 Sesto Fiorentino (FI), Italy
Email:takis@giottobiotech.com
Phone:+393423233750
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