Summary of study ST001151

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000770. The data can be accessed directly via it's Project DOI: 10.21228/M8509V This work is supported by NIH grant, U2C- DK119886.

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Study IDST001151
Study Title4-day dietary effect of fast food vs Mediterranean diet to HDL lipidome
Study TypeDietary intervention study
Study SummaryIn this randomized order cross-over study, ten healthy subjects consumed a Mediterranean (Med) and a fast food (FF) diet for 4 days, with a 4-day wash-out between treatments. Lipidomic composition was analyzed in isolated HDL fractions by an untargeted LC-MS method with 15 internal standards. HDL PE content was increased by FF diet, and 41 out of 170 lipid species were differentially affected by diet. Saturated fatty acids (FA) and odd chain FA were enriched after FF diet, while very-long chain FA and unsaturated FA were enriched after Med diet. The composition of PC, TG and CE were significantly altered to reflect the FA composition of the diet whereas the composition of SM and ceramides were generally unaffected, indicating that glycerolipids may be sensitive markers of dietary intake, whereas sphingolipids are more indicative of non-dietary factors. Results from this study indicate that the HDL lipidome is widely remodeled within 4 days of diet change and that certain lipid classes are more sensitive markers of diet whereas other lipid classes are better indicators of non-dietary factors
Institute
University of California, Davis
DepartmentNutrition
LaboratoryZivkovic
Last NameZivkovic
First NameAngela
Address3402 Meyer hall, Davis, CA, 95616, USA
Emailamzivkovic@ucdavis.edu
Phone+1(530)752-3973
Submit Date2019-03-14
Num Groups4
Total Subjects10
Num Males5
Num Females5
Raw Data AvailableYes
Raw Data File Type(s)ffs-lpd-data.gz
Analysis Type DetailLC-MS
Release Date2019-09-23
Release Version1
Angela Zivkovic Angela Zivkovic
https://dx.doi.org/10.21228/M8509V
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR000770
Project DOI:doi: 10.21228/M8509V
Project Title:Fast Food Project
Project Type:Dietary intervention study
Project Summary:A human study looks at 4-day effect of fast food vs Mediterranean to HDL composition and function, host metabolome and gut microbiome
Institute:University of California, Davis
Department:Department of nutrition
Laboratory:Zivkovic
Last Name:Zivkovic
First Name:Angela
Address:3402 Meyer hall, Davis, CA, 95616, USA
Email:amzivkovic@ucdavis.edu
Phone:+1(530)752-3973
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