Summary of Study ST001285

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000863. The data can be accessed directly via it's Project DOI: 10.21228/M84M57 This work is supported by NIH grant, U2C- DK119886.

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Study IDST001285
Study TitlePOAG and Control Aqueous Humor IROA Metabolites from Veterans Affairs Patients NMR (part-II)
Study Typeuntargeted LC-MS/MS metabolomics IROA
Study SummaryThe AH samples were subjected to 1H-NMR spectroscopy for identification of metabolites using HSQC and TOCSY techniques
Institute
University of Miami
DepartmentOphthalmology, Bascom Palmer Eye Institute
LaboratorySanjoy K. Bhattacharya
Last NameBhattacharya
First NameSanjoy
Address1638 NW 10th Avenue, Miami, FL 33136
EmailSBhattacharya@med.miami.edu
Phone305-482-4103
Submit Date2019-11-26
Num Groups2
Total Subjects41
Raw Data AvailableYes
Raw Data File Type(s)fid
Analysis Type DetailNMR
Release Date2020-01-13
Release Version1
Sanjoy Bhattacharya Sanjoy Bhattacharya
https://dx.doi.org/10.21228/M84M57
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Project:

Project ID:PR000863
Project DOI:doi: 10.21228/M84M57
Project Title:POAG and Control Aqueous Humor IROA Metabolites from Veterans Affairs Patients
Project Type:untargeted LC-MS/MS IROA metabolomics
Project Summary:We performed high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) and Isotopic Ratio Outlier Analysis (IROA) data analysis on aqueous humor patient samples. Samples were collected at asynchronous times.
Institute:University of Miami
Department:Ophthalmology, Bascom Palmer Eye Institute
Laboratory:Sanjoy K. Bhattacharya
Last Name:Bhattacharya
First Name:Sanjoy
Address:1638 NW 10th Avenue, Miami, Florida, 33136, USA
Email:sbhattacharya@med.miami.edu
Phone:3054824103
Contributors:Leila Abdelrahman

Subject:

Subject ID:SU001357
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Gender:Male and female
Species Group:Mammals

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Factor
SA093564Sample032CONTROL
SA093565Sample033CONTROL
SA093566Sample035CONTROL
SA093567Sample031CONTROL
SA093568Sample034CONTROL
SA093569Sample030CONTROL
SA093570Sample027CONTROL
SA093571Sample028CONTROL
SA093572Sample029CONTROL
SA093573Sample036CONTROL
SA093574Sample037CONTROL
SA093575Sample043CONTROL
SA093576Sample044CONTROL
SA093577Sample045CONTROL
SA093578Sample042CONTROL
SA093579Sample041CONTROL
SA093580Sample038CONTROL
SA093581Sample039CONTROL
SA093582Sample040CONTROL
SA093583Sample026CONTROL
SA093584Sample025CONTROL
SA093585Sample021CONTROL
SA093586Sample023CONTROL
SA093587Sample022CONTROL
SA093588Sample024CONTROL
SA093589Sample010POAG
SA093590Sample011POAG
SA093591Sample012POAG
SA093592Sample009POAG
SA093593Sample006POAG
SA093594Sample013POAG
SA093595Sample007POAG
SA093596Sample008POAG
SA093597Sample016POAG
SA093598Sample019POAG
SA093599Sample020POAG
SA093600Sample018POAG
SA093601Sample017POAG
SA093602Sample015POAG
SA093603Sample005POAG
SA093604Sample014POAG
Showing results 1 to 41 of 41

Collection:

Collection ID:CO001351
Collection Summary:Aqueous Humor samples of VA patients with POAG and Control were taken.
Sample Type:Eye tissue
Collection Method:All materials were collected from human donors without identifiers under institutional review board exemption/approval. We acquired 58 aqueous humor (AH) samples from participants at the Veterans Administration (VA) Medical Center (Miami, FL). Patient samples used for 1H-Nuclear Magnetic Resonance (NMR) and Isotopic Ratio Outlier Analysis (IROA) consisted of individuals with POAG (n=23) and non-POAG controls (n=35).

Treatment:

Treatment ID:TR001372
Treatment Summary:No Treatment

Sample Preparation:

Sampleprep ID:SP001365
Sampleprep Summary:Each NMR sample contained 50 μL of volume (45 μL of liquid sample + 5 μL of D2O containing 1.111 mM DSS), with 10% D2O and 0.111 mM DSS.

Analysis:

Analysis ID:AN002129
Analysis Type:NMR
Num Factors:2
Num Metabolites:38
Units:Arbitrary Unites

NMR:

NMR ID:NM000155
Analysis ID:AN002129
Instrument Name:Bruker Avance
Instrument Type:FT-NMR
NMR Experiment Type:2D-1H-1H
Spectrometer Frequency:600 MHz
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