Summary of Study ST001325

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000902. The data can be accessed directly via it's Project DOI: 10.21228/M83D67 This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST001325
Study TitleObesity and Poor Diet as Susceptibility Factors for Secondhand Smoke in Childhood Asthma
Study TypeMS analysis
Study SummaryAim 1: To investigate the effect of SHS exposure on asthma morbidity, systemic inflammation and oxidative stress among inner-city children with asthma. Hypotheses 1.Increasing SHS exposure will be associated with increases in asthma morbidity, systemic inflammation and oxidative stress. Aim 2: To determine if being overweight/obese modifies the effect of SHS exposure on respiratory symptoms, inflammation and oxidative stress responses among inner-city children with asthma.Hypothesis 2. SHS exposure will be associated with a worsened asthma and increases in systemic inflammation and oxidative stress among overweight/obese children compared to normal weight children. Aim 3: To determine if diet quality modifies the effect of SHS exposure on respiratory symptoms, inflammation and oxidative stress responses among inner-city children with asthma. Hypothesis 3. SHS smoke exposure will associated with worsened respiratory symptoms and increases in inflammation and oxidative stress among children with poor quality diet compared those with better quality diet inner-city children with asthma. (Diet will be assessed by dietary inflammatory index, healthy eating index, and additional serum markers proposed in this application).
Institute
University of Michigan
DepartmentBiomedical Research Core Facilities
LaboratoryMetabolomics core
Last NameKachman
First NameMaureen
AddressAnn Arbor, MI
Emailmkachman@med.umich.edu
Phone734-232-0842
Submit Date2020-02-26
Total Subjects185
Study CommentsLow-income minority children in urban areas often inhabit an environment that has excessive pollution and these children are at risk for obesity and poor diet. Secondhand smoke (SHS) is a common exposure in homes of children in Baltimore City and approximately 50-80% of households have a smoker. Secondhand smoke has been associated with worse asthma outcomes. We hypothesize that secondhand smoke exposure will be associated with increases in asthma morbidity and increases in systemic markers of inflammation and oxidative stress and that these responses will be exaggerated among overweight and obese children compared with normal weight and among those with poor diets compared to better diets among children with asthma.
Raw Data AvailableYes
Raw Data File Type(s)d
Chear StudyYes
Analysis Type DetailLC-MS
Release Date2022-08-02
Release Version1
Maureen Kachman Maureen Kachman
https://dx.doi.org/10.21228/M83D67
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

Select appropriate tab below to view additional metadata details:

Project:

Project ID:PR000902
Project DOI:doi: 10.21228/M83D67
Project Title:Obesity and Poor Diet as Susceptibility Factors for Secondhand Smoke in Childhood Asthma
Project Type:MS analysis
Project Summary:Investigating Overweight/Obesity and Poor Diet as Susceptibility Factors for Secondhand Smoke in Childhood Asthma
Institute:Johns Hopkins University School of Medicine
Department:Pulmonary & Critical Care Medicine
Laboratory:McCormack, Meredith Lab
Last Name:McCormack
First Name:Meredith
Address:733 North Broadway, Suite G49 Baltimore, MD 21205-2196
Email:mmccor16@jhmi.edu
Phone:410-955-0036

Subject:

Subject ID:SU001399
Subject Type:Human
Subject Species:Homo sapiens
Taxonomy ID:9606
Species Group:Mammals

Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Sample type Gender
SA096253CS000QCMP-1-02batch pool -
SA096254CS000QCMP-1-03batch pool -
SA096255CS000QCMP-1-04batch pool -
SA096256CS000QCMP-3-06batch pool -
SA096257CS000QCMP-1-01batch pool -
SA096258CS000QCMP-3-04batch pool -
SA096259CS000QCMP-3-05batch pool -
SA096260CS000QCMP-3-03batch pool -
SA096261CS000QCMP-1-10batch pool -
SA096262CS000QCMP-1-11batch pool -
SA096263CS000QCMP-3-07batch pool -
SA096264CS000QCMP-2-01batch pool -
SA096265CS000QCMP-1-09batch pool -
SA096266CS000QCMP-1-08batch pool -
SA096267CS000QCMP-1-06batch pool -
SA096268CS000QCMP-1-07batch pool -
SA096269CS000QCMP-1-05batch pool -
SA096270CS000QCMP-2-11batch pool -
SA096271CS000QCMP-2-10batch pool -
SA096272CS000QCMP-2-09batch pool -
SA096273CS000QCMP-2-08batch pool -
SA096274CS000QCMP-2-02batch pool -
SA096275CS000QCMP-2-12batch pool -
SA096276CS000QCMP-3-02batch pool -
SA096277CS000QCMP-3-01batch pool -
SA096278CS000QCMP-2-07batch pool -
SA096279CS000QCMP-2-06batch pool -
SA096280CS000QCMP-3-11batch pool -
SA096281CS000QCMP-3-10batch pool -
SA096282CS000QCMP-3-09batch pool -
SA096283CS000QCMP-3-12batch pool -
SA096284CS000QCMP-2-03batch pool -
SA096285CS000QCMP-2-05batch pool -
SA096286CS000QCMP-2-04batch pool -
SA096287CS000QCMP-3-08batch pool -
SA096288R00CHRPL1-2-01chear plasma -
SA096289R00CHRPL1-3-01chear plasma -
SA096290R00CHRPL1-3-02chear plasma -
SA096291R00CHRPL1-3-03chear plasma -
SA096292R00CHRPL1-3-04chear plasma -
SA096293R00CHRPL1-2-04chear plasma -
SA096294R00CHRPL1-2-03chear plasma -
SA096295R00CHRPL1-1-02chear plasma -
SA096296R00CHRPL1-1-03chear plasma -
SA096297R00CHRPL1-1-04chear plasma -
SA096298R00CHRPL1-2-02chear plasma -
SA096299R00CHRPL1-1-01chear plasma -
SA096300CS00000MP-2-02master pool -
SA096301CS00000MP-2-04master pool -
SA096302CS00000MP-3-01master pool -
SA096303CS00000MP-3-02master pool -
SA096304CS00000MP-3-03master pool -
SA096305CS00000MP-2-03master pool -
SA096306CS00000MP-2-01master pool -
SA096307CS00000MP-1-01master pool -
SA096308CS00000MP-1-02master pool -
SA096309CS00000MP-1-03master pool -
SA096310CS00000MP-1-04master pool -
SA096311CS00000MP-3-04master pool -
SA096312CS00000RC-1-01red cross plasma -
SA096313CS00000RC-2-04red cross plasma -
SA096314CS00000RC-3-01red cross plasma -
SA096315CS00000RC-3-02red cross plasma -
SA096316CS00000RC-3-03red cross plasma -
SA096317CS00000RC-2-03red cross plasma -
SA096318CS00000RC-2-02red cross plasma -
SA096319CS00000RC-1-02red cross plasma -
SA096320CS00000RC-1-03red cross plasma -
SA096321CS00000RC-1-04red cross plasma -
SA096322CS00000RC-2-01red cross plasma -
SA096323CS00000RC-3-04red cross plasma -
SA096068S00041802Sample female
SA096069S00041895Sample female
SA096070S00041801Sample female
SA096071S00041800Sample female
SA096072S00041804Sample female
SA096073S00041806Sample female
SA096074S00041893Sample female
SA096075S00041808Sample female
SA096076S00041894Sample female
SA096077S00041843Sample female
SA096078S00041805Sample female
SA096079S00041797Sample female
SA096080S00041847Sample female
SA096081S00041789Sample female
SA096082S00041788Sample female
SA096083S00041787Sample female
SA096084S00041792Sample female
SA096085S00041793Sample female
SA096086S00041810Sample female
SA096087S00041845Sample female
SA096088S00041795Sample female
SA096089S00041846Sample female
SA096090S00041872Sample female
SA096091S00041892Sample female
SA096092S00041838Sample female
SA096093S00041873Sample female
SA096094S00041884Sample female
SA096095S00041840Sample female
SA096096S00041880Sample female
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Collection:

Collection ID:CO001394
Collection Summary:Standard blood serum collection
Sample Type:Blood (serum)
Storage Conditions:-80C

Treatment:

Treatment ID:TR001414
Treatment Summary:This is an observational study with no specific treatments applied.

Sample Preparation:

Sampleprep ID:SP001407
Sampleprep Summary:Standard untargeted analysis sample preparation protocol
Sampleprep Protocol Filename:Untargeted_metabolomics_analysis.doc

Chromatography:

Chromatography ID:CH001617
Chromatography Summary:Positive mode RP
Methods Filename:Modified-Pos-LCMS1.m.7z
Instrument Name:Agilent 1290 Infinity II
Column Name:Waters Acquity BEH C18 (100 x 2mm,1.7um)
Chromatography Type:Reversed phase
  
Chromatography ID:CH001618
Chromatography Summary:Negative mode RP
Methods Filename:Modified-Neg-LCMS1.m.7z
Instrument Name:Agilent 1290 Infinity II
Column Name:Waters Acquity BEH C8 (100 x 2.1mm,1.7um)
Chromatography Type:Reversed phase

Analysis:

Analysis ID:AN002204
Analysis Type:MS
Chromatography ID:CH001617
Num Factors:6
Has Rt:1
Rt Units:Minutes
Results File:ST001325_AN002204_Results.txt
Units:Peak area normalized
  
Analysis ID:AN002205
Analysis Type:MS
Chromatography ID:CH001617
Num Factors:6
Has Rt:1
Rt Units:Minutes
Results File:ST001325_AN002205_Results.txt
Units:Peak area normalized
  
Analysis ID:AN002206
Analysis Type:MS
Chromatography ID:CH001618
Num Factors:6
Num Metabolites:178
Rt Units:Minutes
Units:Peak area normalized
  
Analysis ID:AN002207
Analysis Type:MS
Chromatography ID:CH001618
Num Factors:6
Num Metabolites:113
Rt Units:Minutes
Units:Peak area normalized
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